- Tytuł:
- Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers
- Autorzy:
-
Janiszewska, Jolanta
Urbańczyk-Lipkowska, Zofia - Powiązania:
- https://bibliotekanauki.pl/articles/1041270.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
basic dendrimers
nuclear magnetic resonance (NMR).
natural antibacterial peptides
mass spectrometry (MS)
antibiotic resistance - Opis:
- Four low molecular mass lysine dendrimers were synthesized by Boc chemistry in solution (155 and 169) and Fmoc chemistry on solid support (P2 and P13). The structure and fragmentation mode of the above dendrimers was investigated in gas phase by the LSI-MS and ESI-MS techniques. 1H and 13C NMR analysis in solution (d6-DMSO) allowed to confirm the correct structure. Antimicrobial activities of the dendrimers against Staphylococcus aureus, Escherichia coli and Candida albicans confirmed our hypothesis that the dendrimer structure can be used for construction of molecules interacting with biological membranes.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 1; 77-82
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł