- Tytuł:
- Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies
- Autorzy:
-
Rowshanfarzad, P.
Jalilian, A.
Kiyomarsi, M.
Sabet, M.
Karimian, A.
Moradkhani, S.
Mirzaii, M. - Powiązania:
- https://bibliotekanauki.pl/articles/146165.pdf
- Data publikacji:
- 2006
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
rubidium-82m
quality control
animal study
cyclotron - Opis:
- Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.
- Źródło:
-
Nukleonika; 2006, 51, 4; 209-215
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł