Temat: progesterone - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The pattern of steroid secretion by perifused preovulatory rat follicles
Autorzy:: Szoltys, M
Powiązania:: https://bibliotekanauki.pl/articles/70002.pdf
Data publikacji:: 1995
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: radioimmunoassay
steroid production
progesterone
rat follicle
steroid
endocrinology
steroid analysis
ovulation
androgen
animal physiology
gonadotrophin
hormone free
secretion
estradiol
Źródło:: Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Nuclear progesterone receptor isoforms and their functions in the female reproductive tract
Autorzy:: Rekawiecki, R.
Kowalik, M.
Kotwica, J.
Powiązania:: https://bibliotekanauki.pl/articles/32231.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: nuclear receptor
female
reproductive tract
progesterone
isoform
function
embryo
corpus luteum
reproductive system
endocrine gland
ovulation
ovarian follicle
hormone
cattle
animal physiology
Opis:: Progesterone (P4), which is produced by the corpus luteum (CL), creates proper conditions for the embryo implantation, its development, and ensures proper conditions for the duration of pregnancy. Besides the non-genomic activity of P4 on target cells, its main physiological effect is caused through genomic action by the progesterone nuclear receptor (PGR). This nuclear progesterone receptor occurs in two specific isoforms, PGRA and PGRB. PGRA isoform acts as an inhibitor of transcriptional action of PGRB. The inactive receptor is connected with chaperone proteins and attachment of P4 causes disconnection of chaperones and unveiling of DNA binding domain (DBD). After receptor dimerization in the cells’ nucleus and interaction with hormone response element (HRE), the receptor coactivators are connected and transcription is initiated. The ratio of these isoforms changes during the estrous cycle and reflects the different levels of P4 effect on the reproductive system. Both isoforms, PGRA and PGRB, also show a different response to the P4 receptor antagonist activity. Connection of the antagonist to PGRA can block PGRB, but acting through the PGRB isoform, P4 receptor antagonist may undergo conversion to a strongly receptor agonist. A third isoform, PGRC, has also been revealed. This isoform is the shortest and does not have transcriptional activity. Alternative splicing and insertion of additional exons may lead to the formation of different PGR isoforms. This paper summarizes the available data on the progesterone receptor isoforms and its regulatory action within the female reproductive system.
Źródło:: Polish Journal of Veterinary Sciences; 2011, 14, 1
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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