- Tytuł:
- Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer.
- Autorzy:
-
Wilczyńska, Urszula
Kucharska, Anna
Szary, Jarosław
Szala, Stanisław - Powiązania:
- https://bibliotekanauki.pl/articles/1044050.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
angiogenesis
IL-12 gene
tumor gene therapy
angiostatin - Opis:
- We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 4; 1077-1084
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł