- Tytuł:
- Nitrosubstituted analogs of isoxazolines and isoxazolidines: a surprising estimation of their biological activity via molecular docking
- Autorzy:
-
Zawadzińska, Karolina
Gostyński, Bartłomiej - Powiązania:
- https://bibliotekanauki.pl/articles/35126576.pdf
- Data publikacji:
- 2023
- Wydawca:
- Radomskie Towarzystwo Naukowe
- Tematy:
-
isoxazolines
isoxazolidines
molecular docking
molecular dynamics
biological activity
izoksazoliny
izoksazolidyny
dokowanie molekularne
dynamika molekularna
aktywność biologiczna - Opis:
- The biological activities in the field of antimicrobial application of trihalomethylated isoxazolines and isoxazolidines were investigated by means of molecular docking. In our work, we compared these two groups of heterocyclic compounds due to their strength of non-covalent binding affinity with several exemplary proteins that are known to partake in various biological processes. The obtained results show that the investigated compounds possess higher binding affinities to selected proteins than many hitherto known and applied compounds.
- Źródło:
-
Scientiae Radices; 2023, 2, 1; 25-46
2956-4808 - Pojawia się w:
- Scientiae Radices
- Dostawca treści:
- Biblioteka Nauki
Artykuł