- Tytuł:
- Genotype TNF-α(-308) and Silicosis on Factory Workers in Vietnam in 2020
- Autorzy:
-
Nguyen, Viet
Nguyen, Thi Thu Huyen
Dao, Xuan Dat
Vu, Xuan Quy
Pham, Thi Quan
Le, Thi Kim Chung
Tran, Huy Thinh
Le, Thi Huong
Nguyen, Ngoc Anh
Nguyen, Viet Nhung
Nguyen, Ngoc Hong
Luong, Mai Anh
Le, Thi Thanh Xuan - Powiązania:
- https://bibliotekanauki.pl/articles/2020235.pdf
- Data publikacji:
- 2021
- Wydawca:
- Polskie Towarzystwo Przeróbki Kopalin
- Tematy:
-
silicosis
genotype
TNF-α
Vietnam
Wietnam
genotyp - Opis:
- The studFigy aims to determine the TNF-α single-nucleotide polymorphism TNF-α (-308) and assess the association of TNF-a(-308) SNP with the risk of silicosis among workers directly exposed to silica dust in Vietnam. A study was undertaken among 78 cases with silicosis and 103 controls without silicosis in Vietnam. Blood samples were collected for genomic DNA extraction from each subject. The phenotyping of TNF-α(-308) was performed using polymerase chain reaction‐based restriction fragment length polymorphism (PCR‐RFLP) and dye termination sequencing. Results: The average exposure time of the case group was slightly higher than that of the control group (12.46 ± 6.732 years vs. 12.09 ± 7.854 years). The majority of genotypes in both silicosis and non-silicosis was GG. When analyzing the concentration of TNF-α in the study participants' blood, it is shown that the average concentration of TNFα in the case group was higher than that in the control group. The genotype AG in the case group was 1.368 times higher than that in the control group. The percentage of all A alleles in the case group with silicosis was 1.342 times higher than the control group without the disease, similar to previous studies. Conclusion: The majority of genotypes in both groups was GG. The average concentration of TNF-α in blood, genotype AG, and the percentage of all A alleles in the case group was higher than that in the control group.
- Źródło:
-
Inżynieria Mineralna; 2021, 2; 459--466
1640-4920 - Pojawia się w:
- Inżynieria Mineralna
- Dostawca treści:
- Biblioteka Nauki
Artykuł