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    Wyświetlanie 1-11 z 11
    Tytuł:
    Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4plus and CD8plus T cells in calves
    Autorzy:
    Maslanka, T
    Jaroszewski, J.J.
    Markiewicz, W.
    Jabubowski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/31556.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    peripheral blood
    T cell
    calf
    CD4plus T cell
    CD8plus T cell
    apoptosis
    meloxicam
    flunixin meglumine
    lymphocyte
    antiinflammatory drug
    Opis:
    The aim of the study was to determine whether treatment with recommended doses of meloxicam or flunixin had an effect on the apoptosis of peripheral blood T lymphocytes in calves. The study was carried out on 4-5 months old calves (n = 24, 8 per group). Experimental animals were injected subcutaneously with a single dose of 0.5 mg . kg-1 of meloxicam or intravenously with 3 doses of 2.2 mg . kg-1 day-1 of flunixin. The non-treatment animals served as control. Blood samples were taken at day 0 and at days 1, 2, 3, 5, 7 and 14 after the first NSAIDs injection. Apoptosis was determined by flow cytometry using Annexin V-PE/7-AAD staining. The kinetic analysis of apoptosis in the total lymphocyte population, as well as in the CD4+ and CD8+ subsets did not reveal significant differences in the frequency of early apoptotic cells between control and experimental groups throughout the period studied. Although, 24 h after administration of the first dose of NSAIDs, late-stage apoptosis/necrosis was significantly increased in the total lymphocyte population (the meloxicam group), as well as in the CD4+ (the meloxicam group and the flunixin group) and CD8+ (the flunixin group) subsets of T cells. However, this disturbance was transient, relatively poorly expressed and, thus, unlikely to be of clinical significance. Our results indicate that the use of meloxicam or flunixin in accordance with the recommended dosage regimen in cattle do not have a clinically significant influence on apoptosis of peripheral blood T cells.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 1; 3-12
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children
    Autorzy:
    Kotłowska-Kmieć, Aldona
    Bąkowska, Alicja
    Szarszewski, Adam
    Kamińska, Barbara
    Łuczak, Grażyna
    Radys, Wojciech
    Landowski, Piotr
    Brodzicki, Jacek
    Korzon, Maria
    Liberek, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1040535.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    T cell
    H. pylori
    FasL
    Fas
    apoptosis
    lymphocyte
    Opis:
    The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 3; 433-438
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    IgG antibody and eosinophil responses during heterologous infection of BALB-c mice with Trichinella spiralis and Heligmosomoides polygyrus
    Autorzy:
    Doligalska, M.
    Mijal, J.
    Laskowska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/840273.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    T helper cell
    parasite
    mouse
    mice
    host response
    heterologous infection
    eosinophil
    Heligmosomoides polygyrus
    Trichinella spiralis
    T cell
    antibody
    Źródło:
    Annals of Parasitology; 1998, 44, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Experimental inflammatory bowel disease - role of T cells
    Autorzy:
    Szczepanik, M.
    Gryglewski, A.
    Bryniarski, K.
    Stachura, J.
    Ptak, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/70282.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    myeloperoxidase
    B lymphocyte
    inflammatory bowel disease
    chronic colitis
    colitis
    T cell
    Źródło:
    Journal of Physiology and Pharmacology; 2000, 51, 2
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state - case report
    Autorzy:
    Kuczynska, M.
    Dziaduch, E.
    Grzywa-Celinska, A.
    Lachowska-Kotowska, P.
    Mosiewicz, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/3662.pdf
    Data publikacji:
    2014
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    acute liver failure
    liver function
    female patient
    hepatic cirrhosis
    T cell
    lymphoma cell
    remission state
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lymphocyte subpopulations and apoptosis of immune cells in rabbits experimentally infected with a strain of the RHD virus having a variable haemagglutination capacity
    Autorzy:
    Niedzwiedzka-Rystwej, P.
    Deptula, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/31022.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    lymphocyte subpopulation
    apoptosis
    immune cell
    rabbit
    experimental infection
    RHD virus
    hemagglutination capacity
    granulocyte
    T cell
    B cell
    Opis:
    The paper describes the immunological response in the matter of percentage of T cells (receptor CD5+) and subpopulations (Th with receptor CD4+, Tc/Ts with receptor CD8+, T with receptor CD25+) and B cells with receptor CD19+, as well as the percentage of apoptotic granulocytes and lymphocytes, in rabbits experimentally infected with the Hagenow strain of the RHD virus. The material chosen for the experiment is special, as among all strains of RHD virus, there are only two strains which carry the variable haemagglutination capacity of red cells. The results of the study show that the Hagenow strain gives an untypical picture of T and B lymphocytes, whereas the results in inducing apoptosis seems to corespond with previous data, confirming the inclusion of apoptosis from 4 h p.i. and the intensity of the phenomenon being higher in granulocytes.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification of CD4plus T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking
    Autorzy:
    Francis, D.
    Kumar, A.
    Chittalakkottu, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096359.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    CD4+
    T cell
    epitope prediction
    secretory proteins
    Staphylococcus aureus
    peptide vaccine
    molecular docking
    Opis:
    One major reason for the lack of clinical success of Staphylococcus aureus vaccine candidates is the inability of the antigens to develop a CD4+ T cell-mediated immune response. Hence, it is important to identify CD4+ T cell antigens from S. aureus. CD4+ T cells are activated following the presentation of epitopes derived from exogenous proteins on HLA class II molecules. Fifty-nine secretory proteins of S. aureus were analyzed computationally for the presence of HLA class II binding peptides. Fifteen-mer peptides were generated, and their binding to 26 HLA class II alleles was predicted. The structural feasibility of the peptides binding to HLA-II was studied using molecular docking. Of the 16,724 peptides generated, 6991 (41.8%) were predicted to bind to any one of the alleles with an IC50 value below 50 nM. Comparative sequence analysis revealed that only 545 of the strong binding peptides are non-self in the human system. Approximately 50% of the binding peptides were monoallele-specific. Moreover, approximately 95% of the predicted strong binding non-self peptides interacted with the binding groove of at least one HLA class II molecule with a glide score better than !10 kcal/mol. On the basis of the analysis of the strength of binding, non-self presentation in the human host, propensity to bind to a higher number of alleles, and energetically favorable interactions with HLA molecules, a set of 11 CD4+ T cell epitopes that can be used as vaccine candidates was identified.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 43-54
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytopathology of canine lymphomas (100 cases)
    Autorzy:
    Sapierzynski, R.
    Micun, J.
    Jagielski, D.
    Jurka, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/31296.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cytopathology
    canine lymphoma
    lymphoma
    dog
    malignant lymphoma
    tumour
    animal disease
    occurrence
    T cell
    biopsy
    Opis:
    Malignant lymphoma is one of the most common malignant tumours occurring in dogs. Fine needle aspiration biopsy (FNAB) is an excellent, specific diagnostic procedure used to assess pathological processes in lymph nodes. The aim of the present study was to conduct a cytopathological analysis of lymphoma in dogs and to analyse some epidemic aspects of occurrence of lymphoma in 100 dogs using Giemsa stained slides. Samples were obtained by fine needle aspiration biopsy, fine needle non-aspiration biopsy, lymph node impression smears and by examination of body cavity effusions. The determination of the type and subtype of tumour was made on the basis of the updated Kiel classification adopted for dogs. Based on cytopathological analysis, the lymphoma was diagnosed in 100 dogs: 44 were female and 56 male. The animals’ age ranged from 1.5 year to 15 years (median: 7.5 years), the animals were of different breeds (72% of all dogs belonged to 28 different breeds) and crossbreeds (28%). In 29% of dogs the regional or general lymphadenomegaly was the only clinical sign observed, in remaining cases (71%) at least one abnormality connected to lymphoma was found. Among all diagnosed lymphomas, high-grade lymphomas were more prevalent (86% of all cases) than low-grade lymphomas (14% of all cases). The possibility of boxers having a predisposition to T cell lymphoma development could be also suspected.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnosis of Pneumocystis carinii infection by a serum polymerase chain reaction
    Autorzy:
    Golab, E.
    Sobolewska, A.
    Dzbenski, T.
    Bitkowska, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/836353.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Pneumocystis carinii
    infection
    serum
    diagnosis
    laboratory diagnosis
    pneumonia
    polymerase chain reaction
    rRNA gene
    T cell
    Źródło:
    Annals of Parasitology; 1998, 44, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The presence of CD25 on bovine WC1 plus gamma delta T cells is positively correlated with their production of IL-10 and TGF-beta, but not IFN-gamma
    Autorzy:
    Maslanka, T.
    Jaroszewski, J.J.
    Markiewicz, W.
    Ziolkowski, H.
    Barski, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/32183.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cattle
    WC1 cell
    T cell
    T lymphocyte
    transforming growth factor-beta
    interleukin 10
    interferon-gamma
    CD25 antigen
    CD25 molecule
    Opis:
    WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-γ and IL-10 seems to be related to WC1+ cells’ effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells. Due to increasingly frequent emphasised role of consumption of IL-2 in the mechanism of suppressor action of mouse CD25+CD4+ T regulatory cells, expression of the receptor’s α chain for interleukin 2 (CD25) on WC1+ lymphocytes has been evaluated. An average of 5.21% of WC1+ cells obtained from PBMCs of 12-month-old heifers show constitutive expression of the CD25 molecule, with CD25highWC1+ and CD25lowWC1+ cells accounting for 1.05% and 4.10% of WC1+ lymphocytes, respectively. For detection of intracellular cytokine production, PBMCs were stimulated with concanavalin A. Both IFN-γ- and IL-10-producing cells within the CD25-WC1+ and CD25+WC1+ subpopulations were mainly separate subpopulations. The average percentage of IFN-γ+IL-10-, IFN-γ-IL-10+ and IFN-γ+IL-10+ cells among CD25-WC1+ lymphocytes was 4.03%, 2.67% and 0.51%, respectively. A positive correlation was observed between the presence of the CD25 molecule on WC1+ lymphocytes and production of IL-10 and TGF-β, because the average percentage of IFN-γ-IL-10+ and IFN-γ+IL-10+ among CD25+WC1+ lymphocytes was 3 and 4.5 times higher as compared to the corresponding cells in the CD25-WC1+ subpopulation, whereas the percentage of IFN-γ+IL-10- cells in both the subpopulations was not significantly different. The percentage of TGF-β+ cells within the CD25+WC1+ subpopulation was 2.72 times as high as that of CD25-WC1+ lymphocytes. Therefore, with respect to the production of IFN-γ, IL-10 and TGF-β, CD25+WC1+ lymphocytes turn out to have a more suppressor profile than CD25-WC1+.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of chlorpyrifos on the profile of subpopulations immunocompetent cells B, T and NK in in vivo model
    Autorzy:
    Noworyta-Glowacka, J.
    Beresinska, M.
    Bankowski, R.
    Wiadrowska, B.
    Siennicka, J.
    Ludwicki, J.K.
    Powiązania:
    https://bibliotekanauki.pl/articles/875152.pdf
    Data publikacji:
    2014
    Wydawca:
    Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
    Tematy:
    chlorpyrifos
    pesticide
    human exposure
    immunomodulation
    B cell
    T cell
    natural killer cell
    in vivo model
    immune system
    lymphocyte
    organophosphorus pesticide
    Opis:
    Background. Current studies have indicated many environmental factors, such as pesticides, that cause immune system disorders through inducing changes in humoral and cellular responses thereby increasing the risk of contracting infectious diseases and cancer. The literature suggests that low exposures to certain organophosphorus pesticides stimulate the immune system, whilst high exposures result in decreased function. Precise mechanisms for the fall in immunocompetence are often unclear, however it can be predicted that the intimate interaction between the nervous and immune systems can potentially lead to toxicity. Objectives. To determine the effects of organophosphorus pesticide, chlorpyrifos that is often used in Poland, on selected immunological responses, such as immune-competent cell proportions formed experimentally in-vivo by cells of Wistar rats during subchronic exposures after 45 and 90 days. Materials and Methods. The test was carried out on ten male and ten female Wistar rats in each of three test groups, who received 3 chlorpyrifos doses for 90 days intragastrically, according to OECD guidelines (No. 401). Two control groups were given olive oil. After completion, the animals were deeply anaesthetised by a mixture of ketamine (Vetaketam) and xylazine (Vetaxym). Immuno-competent cells were profiled by a commercial monoclonal antibody method. In order to measure the dynamics of any changes, the aforementioned immunological responses were investigated after 45 days using the same procedures for obtaining the relevant biological test material. Results. Test animals exposed to chlorpyrifos had altered number of white bood cells which were either increased or decreased relative to controls after 45 and 90 days for all exposure levels used. Conclusions. The study demonstrated changes in white-blood cell (lymphocyte) response profiles, reflecting an immunomodulation although such changes were equivocal, where both suppression and stimulation were observed.
    Wprowadzenie. Współczesne badania naukowe wskazują, iż wiele czynników środowiskowych, wliczając w to pestycydy, powoduje zaburzenia układu odpornościowego poprzez indukowanie zmian w odpowiedzi humoralnej i komórkowej, co w efekcie może prowadzić do zwiększonej zapadalności na choroby zakaźne i nowotworowe. Doniesienia literaturowe sugerują, że niskie poziomy narażenia na niektóre pestycydy fosforoorganiczne powodują stymulację układu odpornościowego, zaś wyższe, obniżenie funkcji immunologicznych. W wielu przypadkach nie jest poznany dokładny mechanizm spadku odporności, jednak poprzez związek funkcji neurologicznych i immunologicznych można przewidzieć potencjalne skutki działania toksycznego. Cel. Celem badań było określenie wpływu chloropiryfosu na wybrane parametry odpowiedzi immunologicznej, takie jak skład odsetkowy komórek immunokompetentnych w modelu doświadczalnym in vivo szczurów laboratoryjnych szczepu Wistar, w trakcie ekspozycji subchronicznej 45 i 90 dniowej. Materiał i metody. Badanie wykonano na samcach (10 szt.) i samicach (10 szt.) szczurów rasy Wistar. Zwierzętom z grupy badanej podawano dożołądkowo chloropiryfos przez 90 dni, zgodnie z zaleceniami OECD (Guideline No 401). Grupa kontrolna otrzymywała oliwę z oliwek. Po zakończeniu eksperymentu zwierzęta poddawano głębokiej narkozie przy użyciu mieszaniny: ketaminy (Vetaketam) i ksylazyny (Vetaxym). W celu określenia dynamiki ewentualnych zmian zbadano wyżej wymienione parametry immunologiczne po 45 dniach doświadczenia przy zachowaniu tych samych procedur uzyskania materiału badawczego. Wyniki. Uzyskane wyniki wskazują, że narażanie zwierząt doświadczalnych na chloropiryfos zmieniało skład odsetkowy komórek immunokompetentnych w modelu doświadczalnym in vivo zwiększając albo zmniejszając ich wartość w stosunku do poziomów oznaczonych u grupy zwierząt kontrolnych po 45 i 90 dniowej ekspozycji i na wszystkich poziomach narażania. Wnioski. Odnotowane w wyniku przeprowadzonych badań zmiany w profilu białokrwinkowym świadczące o działaniu immunomodulującym były niejednoznaczne przyjmując formę zarówno immunosupresji jak i immunostymulacji.
    Źródło:
    Roczniki Państwowego Zakładu Higieny; 2014, 65, 4
    0035-7715
    Pojawia się w:
    Roczniki Państwowego Zakładu Higieny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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