- Tytuł:
- Preparation and biodistribution of [201Tl](III)vancomycin complex in normal rats
- Autorzy:
-
Jalilian, A.
Hosseini, M.
Karimian, A.
Saddadi, F.
Sadeghi, M. - Powiązania:
- https://bibliotekanauki.pl/articles/146167.pdf
- Data publikacji:
- 2006
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
thallium-201
vancomycin
labeling
SPECT
radiopharmaceuticals
infection - Opis:
- Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN. The best results were obtained at room temperature in water after 30 min with a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak. The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity of more than 98 š 1% by RTLC. A specific activity of about 4.14 x 1010 Bq/mmol was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and in presence of human serum was determined up to 5.5 days. Biodistribution study of 201Tl(III)-vancomycin in normal rats was performed up to 52 h.
- Źródło:
-
Nukleonika; 2006, 51, 4; 203-208
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł