Temat: miRNA - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Regulatory RNAs in Planarians
Autorzy:: Pawlicka, Kamila
Perrigue, Patrick
Barciszewski, Jan
Powiązania:: https://bibliotekanauki.pl/articles/1038722.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: planarians
RNAi
miRNA
regeneration
stem cells
Opis:: The full scope of regulatory RNA evolution and function in epigenetic processes is still not well understood. The development of planarian flatworms to be used as a simple model organism for research has shown a great potential to address gaps in the knowledge in this field of study. The genomes of planarians encode a wide array of regulatory RNAs that function in gene regulation. Here, we review planarians as a suitable model organism for the identification and function of regulatory RNAs.
Źródło:: Acta Biochimica Polonica; 2016, 63, 4; 681-686
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: AmiRNA Designer - new method of artificial miRNA design
Autorzy:: Mickiewicz, Agnieszka
Rybarczyk, Agnieszka
Sarzynska, Joanna
Figlerowicz, Marek
Blazewicz, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/1038843.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: artificial miRNA
RNAi
gene regulation
sequence specific
thermodynamic profiles
Opis:: MicroRNAs (miRNAs) are small non-coding RNAs that have been found in most of the eukaryotic organisms. They are involved in the regulation of gene expression at the post-transcriptional level in a sequence specific manner. MiRNAs are produced from their precursors by Dicer-dependent small RNA biogenesis pathway. Involvement of miRNAs in a wide range of biological processes makes them excellent candidates for studying gene function or for therapeutic applications. For this purpose, different RNA-based gene silencing techniques have been developed. Artificially transformed miRNAs (amiRNAs) targeting one or several genes of interest represent one of such techniques being a potential tool in functional genomics. Here, we present a new approach to amiRNA*design, implemented as AmiRNA Designer software. Our method is based on the thermodynamic analysis of the native miRNA/miRNA* and miRNA/target duplexes. In contrast to the available automated tools, our program allows the user to perform analysis of natural miRNAs for the organism of interest and to create customized constraints for the design stage. It also provides filtering of the amiRNA candidates for the potential off-targets. AmiRNA Designer is freely available at http://www.cs.put.poznan.pl/arybarczyk/AmiRNA/.
Źródło:: Acta Biochimica Polonica; 2016, 63, 1; 71-77
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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