- Tytuł:
- Possible computational filter to detect proteins associated to influenza A subtype H1N1
- Autorzy:
-
Polanco, Carlos
Buhse, Thomas
Castañón-González, Jorge
Samaniego, José - Powiązania:
- https://bibliotekanauki.pl/articles/1039197.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
Polarity Index Method
influenza A virus subtype H1N1
drug design
QSAR method - Opis:
- The design of drugs with bioinformatics methods to identify proteins and peptides with a specific toxic action is increasingly recurrent. Here, we identify toxic proteins towards the influenza A virus subtype H1N1 located at the UniProt database. Our quantitative structure-activity relationship (QSAR) approach is based on the analysis of the linear peptide sequence with the so-called Polarity Index Method that shows an efficiency of 90% for proteins from the Uniprot Database. This method was exhaustively verified with the APD2, CPPsite, Uniprot, and AmyPDB databases as well as with the set of antibacterial peptides studied by del Rio et al. and Oldfield et al.
- Źródło:
-
Acta Biochimica Polonica; 2014, 61, 4; 693-698
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł