- Tytuł:
- A paradigm shift in the role of NSAIDs in COVID-19: new pathological mechanisms and potential treatment targets
- Autorzy:
-
Ilie, Petre Cristian
Stefanescu, Simina
Veronese, Nicola - Powiązania:
- https://bibliotekanauki.pl/articles/1491092.pdf
- Data publikacji:
- 2020-09-20
- Wydawca:
- Atena Research Association
- Tematy:
-
Paradigm Shift
NSAIDs
Covid-19
COX-2 inhibitors - Opis:
- Objectives: The pathogeny of SARS-COV2 infection is currently not well defined. In this paper, we present a new perspective of how the SARS-CoV2 infection can lead to severe cases and potential pathways of preventing such cases. Methods: In the first part, we describe the role of cyclooxigenase 2 and in the second part, we describe the role of hypoxia inducible factor (HIF). Findings: We hypothesize that cyclooxigenase 2 and hypoxia inducible factor with subsequent inflammation and hypoxia can up-regulate each other in a vicious circle of feed-forward that can ultimately lead to “cytokine storm”. Conclusions: Breaking this cycle early potentially will have beneficial effects either by improving oxygenation (oxygen being given earlier in the course of the treatment) or by inhibiting COX-2. We also believe, that the use of COX-2 inhibitors early in the course of the disease can improve the outcome and clinical trial are urgently needed.
- Źródło:
-
Atena Journal of Public Health; 2020, 2; 6-6
2695-5911 - Pojawia się w:
- Atena Journal of Public Health
- Dostawca treści:
- Biblioteka Nauki
Artykuł