Wszystkie pola: Paracetamol - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Nephroprotective role of Potentilla reptans L. aqueous extract on paracetamol - induced kidney nephrotoxicity in male mice
Autorzy:: Muthulingam, M.
Prabhahar, C.
Senthilmurugan, S.
Pugazhendy, K.
Vijayan, P.
Baranitharan, M.
Powiązania:: https://bibliotekanauki.pl/articles/1839819.pdf
Data publikacji:: 2021
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Nephroprotective
Nephrotoxicity
Paracetamol
Silymarin
Potentilla reptans
Opis:: Nephroprotective effects (NPE) of simple Potentilla reptans - aqueous leaf extract (Pr-ALE) leaves on Paracetamol induced kidney poisonousness in wistar rats. Adult male wistar rats (weight range (WR): 200-220g) were divided into 6 groups (n=6). Paracetamol (PA) and Silymarin (SY) stayed managed intraperitoneally arranged the 5th day to rats in all groups but the normal control. Furthermore, a significant nephroprotective (NP) of the aqueous leaf extract (ALE) and oral dose of PA and SY. Pr-ALE did not mortality or significant changes in the body weight. Progression of nephrotoxicity (NT) induced by PA in rats was interfered by Pr-ALE managed, and these effects were correspond to those managed with SY. This is the first record on NPE of Pr against PA-induced NT.
Źródło:: World News of Natural Sciences; 2021, 39; 76-85
2543-5426
Pojawia się w:: World News of Natural Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Comparative Test of Physicochemical Parameters and Microbiological Quality of Different Brands of Paracetamol Tablets Sold in Nigeria
Autorzy:: Alabere, Hafsat O.
Lucky, Efe I.
Ogundare, A. O.
Akinwunmi, Abeeb I.
Abimbola, Titilope Y.
Powiązania:: https://bibliotekanauki.pl/articles/1031840.pdf
Data publikacji:: 2020
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Acetaminophen
British Pharmacopoeia (BP)
Good Manufacturing Practice
Paracetamol
Pharmaceutical quality
UV/Visible Spectrophotometer
United States Pharmacopoeia (USP)
Opis:: Paracetamol also known as acetaminophen is a widely used antipyretic and analgesic agent. The therapeutic efficacy of pharmaceutical products depends on both microbial and physicochemical qualities of the products, hence, the need to routinely assess the pharmaceutical quality of the available brands of the tablets to ensure they conform to standard specifications. This study was done to evaluate the microbial and physicochemical qualities of 10 brands of paracetamol tablets sold in Nigeria. The purchased drug samples were evaluated for their uniformity of weight, crushing strength, friability, disintegration time, total viable aerobic count and content of active ingredient. These tests were performed by standard methods and techniques following official pharmacopoeia protocols. The investigated 10 brands of paracetamol tablets passed the standards of the British Pharmacopoea (BP) regarding microbial specifications. The tablets were uniform in weight with crushing strength 5 KgF - 12 KgF except a brand with crushing strength ranging between 15 KgF – 18 KgF and another brand which has no crushing strength. The disintegration times were within 15 minutes except a brand with a disintegration time of 27 minutes 44 seconds. Friability values were less than 1%. The % content of paracetamol as an active ingredient in the tablets ranges from 90-110%. 8 out of 10 brands of the paracetamol tablets assessed met all compendia standards. However, products of good quality can be guaranteed through quality control and adherence to the provisions of good manufacturing practices. Also, a routine sentinel market surveillance of pharmaceutical products is encouraged.
Źródło:: World Scientific News; 2020, 141; 12-23
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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