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    Wyświetlanie 1-3 z 3
    Tytuł:
    Clinical Manifestations of Plasmodium berghei ANKA Infection in Juvenile Mice: A Short Case Report
    Autorzy:
    Ajayi, J. B.
    Agbeyangi, A. O.
    Daniel, A.
    Omobolaji, I.
    Mogaji, H. O.
    Powiązania:
    https://bibliotekanauki.pl/articles/1113684.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    ECM
    Juvenile
    Malaria
    Mice
    Neonates
    Plasmodium berghei
    Opis:
    Malaria is an important health and development challenge in Africa, Animal models most particularly mice, have long been employed to study malaria pathogenesis. This paper describes clinical manifestations due to Plasmodium berghei ANKA infection in juvenile mice as a model for understanding the complications of congenital malaria in neonates. Forty-five juvenile mice (5-7 days old) were acquired from University College Hospital, Ibadan and injected with 2×107 (0.2 ml) Plasmodium berghei ANKA parasitized red blood cells (PRBCs). The mice were then transported to the study site, kept in well-ventilated cages and fed daily with a balanced ration. Post-P. berghei infection, the mice were monitored daily for mortality. Clinical manifestations of experimental cerebral malaria (ECM) were assessed and confirmed if at least ruffled fur, hunching, wobbly gait, limb paralysis, convulsions, or coma was observed. Each sign was given a score of 1. Animals with scores ≥4 were considered to have severe ECM. In the experiment, 20 (44%) mice were lost due to natural cause (i.e. stress) at day 2. Between day 4 and 9, 25 (56%) of the study mice presented clinical signs of ECM. This included: ruffled fur – 25 (100%), hunching - 21 (84%), wobbly gait - 17 (68%), limb paralysis - 20 (80%), convulsions - 25 (100%). Survival rate and severity of ECM in the mice differs, 22 (88.0%) had severe ECM and 3 (12.0%) had mild ECM. This study has shown that parasite establishment and malaria complications can manifest as early as 4 days’ post P. berghei infection in 5-7 days old mice.
    Źródło:
    World News of Natural Sciences; 2017, 14; 90-96
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy of Rectal Artesunate on Parasitaemia and Febrile Condition of Children of Ogun State, South-Western Nigeria
    Autorzy:
    Agbeyangi, O. A.
    Sam-Wobo, S. O.
    Ekpo, U. F.
    Akinloye, O. A.
    Mafiana, C. F.
    Powiązania:
    https://bibliotekanauki.pl/articles/1179244.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Children
    Efficacy
    Febrile Condition
    Malaria
    Ogun State
    Parasitaemia
    Pre-Referral
    Rectal Artesunates
    South-Western Nigeria
    Opis:
    Efficacy of Rectal Artesunate on parasitaemia and febrile condition of children was assessed in 905 children below the age of 5 years. Grid systematic method was employed in selecting sixteen study centres from 8 Local Government Areas of Ogun State. Ethical approvals were obtained in addition to interactive sessions with parents of the children and PHCs medical practitioners. Body weight and temperature were taken and drug was administered at a dose of 5 to 10mg/kg of the body weight per rectum at 0 hour, 24 hours and 48 hours. Efficacy of treatment was monitored by analysing blood samples taken at 0 hour, 24 hours and 48 hours for Malaria Parasites Count (MPC/µl), parasitized red blood cells (PRBC). Data obtained were analyzed using SPSS version 20 to assess association with p-value of < 0.05. A significant (p < 0.05) difference was observed between malaria parasites prevalence at 0 hour, 24 hours and 48 hours. Also a baseline mean malaria parasite density (MPC/µl) of 3,320/μl was observed at 0 hour and a reduction in mean MPC/µl of 1,230/μl and 420/μl at 24 hours and 48 hours respectively with a significant (p < 0.05) difference between MPC/µl at 0 hour, 24 hours and 48 hours. Baseline mean parasitized red blood cells (PRBC) of 4.2 % was observed at 0 hour with reduction in mean PRBC of 2.4 % and 1.1 % at 24 and 48 hours respectively with a significant (p < 0.05) difference between PRBC at 0 hour, 24 hours and 48 hours. Fever Subsidence Ratio between 0 hour, 24 hours and 48 hours were 1.4:1.1. Rectal artesunate is highly effective and well tolerated antimalarial suppository for pre-referral and parenteral therapy.
    Źródło:
    World Scientific News; 2017, 80; 116-142
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Impact of Rectal Artesunate on Haematological Parameters of Children of Ogun State, South-Western Nigeria
    Autorzy:
    Agbeyangi, O. A.
    Sam-Wobo, S. O.
    Ekpo, U. F.
    Akinloye, O. A.
    Mafiana, C. F.
    Powiązania:
    https://bibliotekanauki.pl/articles/1179588.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Anaemia
    Children
    Effectiveness
    Malaria
    Ogun State
    Rectal Artesunates
    South-western Nigeria
    Opis:
    Impact of Rectal Artesunate on haematological parameters was assessed in 905 children below the age of 5 years. Grid systematic method was employed in selecting sixteen study centres from 8 Local Government Areas of Ogun State. Ethical approvals were obtained in addition to interactive sessions with parents of the children and PHCs medical practitioners. Drug was administered at a dose of 5 to 10mg/kg of the body weight per rectum at 0 hour, 24 hours and 48 hours. Data obtained were analyzed using SPSS version 20 to assess association with p-value of < 0.05. Impact of Rectal Artesunate was monitored by analysing blood samples taken at 0 hour, 24 hours and 48 hours for Packed Cells Volume (PCV) and Haemoglobin concentration (Hb). There was a significant (p < 0.05) increase in baseline PCV (L/L) and Hb (g/L) during 48 hours across the LGAs. Parasitaemia (MPC/µl) in children has a significant (p < 0.05) association with anaemia (PCV and Hb) and was positively correlated (r = +0.348 and r =+ 0.201). A significant (p < 0.05) difference observed between MCV (fl), MCH (pg) and MCHC (g/L) at 0 hour and MCV (fl), MCH (pg) and MCHC (g/L) at 48 hours. More awareness on the use of Rectal Artesunate in reducing anaemia due to malaria in children should be created since it is highly effective antimalarial suppository.
    Źródło:
    World Scientific News; 2017, 74; 80-93
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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