- Tytuł:
- Design, synthesis and biological evaluation of a new bridged immunosuppressor.
- Autorzy:
-
Szewczuk, Zbigniew
Wilczyński, Andrzej
Petry, Inga
Siemion, Ignacy
Wieczorek, Zbigniew - Powiązania:
- https://bibliotekanauki.pl/articles/1044065.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
chemical synthesis
MS-MS sequencing
histocompatibility antigen
bridged analog
HLA-DQ
RGD-sequence
MHC class-II - Opis:
- A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-γ-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 4; 1147-1150
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł