- Tytuł:
- Synthesis, Characterization and biological activity of various substituted (E)-5-benzylidene-2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)amino)thiazol-4(5H)-one derivatives
- Autorzy:
-
Tejani, Rasik
Mokariya, Devang
Manwar, Rohit
Shah, Manish K. - Powiązania:
- https://bibliotekanauki.pl/articles/1076007.pdf
- Data publikacji:
- 2019
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
In vitro antibacterial
antibacterial
antifungal
oxadiazole
thiazolone - Opis:
- 2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole was synthesized via reaction of chloroacetic acid with 4-nitrobenzohydrazide in phosphonyl chloride(4). Compound 4 was treated with 4-aminophenol to form 4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)aniline(5) having free -NH2 group,which is reacted with chloroacetyl chloride to give 2-chloro-N-(4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)acetamide(6). Compound 6 was cyclized by ammonium thiocyanate to form 2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)amino)thiazol-4(5H)-one(7) with thiazolone ring. Compound was reacted different aldehydes to form (E)-5-benzylidene -2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl) methoxy)phenyl) amino)thiazol-4(5H)-one derivatives(8a-j). In vitro antibacterial activity of the target compounds were investigated using two types of bacteria, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The results indicated that the newly synthesized (E)-5-benzylidene-2-((4-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methoxy) phenyl)amino)thiazol-4(5H)-one derivatives (compounds 8d and 8f) showed enhanced activity against Gram-negative bacteria when compared with that of the control drug (gentamycin).
- Źródło:
-
World Scientific News; 2019, 118; 265-272
2392-2192 - Pojawia się w:
- World Scientific News
- Dostawca treści:
- Biblioteka Nauki
Artykuł