Temat: IL-1β - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Mutual relations between the amygdala and pro-inflammatory cytokines: IL-1β and IL-6
Autorzy:: Czerwiec, Katarzyna
Ruciński, Jan
Piwko, Grzegorz
Myślińska, Dorota
Kosiński, Adam
Powiązania:: https://bibliotekanauki.pl/articles/2203182.pdf
Data publikacji:: 2022-05-31
Wydawca:: Gdański Uniwersytet Medyczny
Tematy:: inflammation
IL-6
amygdala
IL-1β
Opis:: Interleukin 1 (IL-1) and interleukin 6 (IL-6) are typical examples of multfunctonal pro-infammatory cytokines involved in the regulaton of the immune response, hematopoiesis, and infammaton. Both peripheral and intraventricular administraton of these cytokines causes acute phase symptoms, e.g. fever, actvaton of the hypothalamic-pituitary-adrenal axis and psychological depression. The amygdala belongs to the structures of the limbic system involved in the regulaton of the immune response. Increased actvity of immune system may lead to changes in the role of amygdala, medial prefrontal cortex, anterior cingulate cortex or insula. The aim of the study was to present the mutual interactons between the amygdala and pro-infammatory cytokines such as interleukin-1β (IL-1 beta) and interleukin 6 (IL-6). Most of the data included in this review comes from animal studies.
Źródło:: European Journal of Translational and Clinical Medicine; 2022, 5, 1; 40-46
2657-3148
2657-3156
Pojawia się w:: European Journal of Translational and Clinical Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The relation between glutathione S-Transferase M1 null-genotype and cardiac problems in beta-thalassemia
Autorzy:: Abo-Shanab, Asem
El-Desouky, Mohamed
Kholoussi, Naglaa
El-Kamah, Ghada
Helwa, Iman
Powiązania:: https://bibliotekanauki.pl/articles/1038809.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: GSTM1
β-thalathemia
Cardiac complications
hs-CRP
IL-6
Opis:: This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia. Materials and Methods. The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, group II: 56 β-thalassemic patients and group III: 16 β-thalassemic patients with cardiac complications were taken from group II). The measurement of human high sensitive C-reactive protein (hs-CRP) was performed using nephelometry. GSTM1 genotype was detected by Polymerase Chain Reaction (PCR) and cardiac complications were determined by using Echocardiography. Results. A statistically significant increase in hs-CRP and interleukin-6 (IL-6) levels was found in β-thalassemic patients with cardiac complications compared to normal subjects. Results showed no relation between GSTM1 null genotype frequency neither with β-thalassemia nor with cardiac complications appearance, where the interaction between GSTM1 null genotype in β-thalassemic patients with cardiac complications and healthy subjects were insignificant compared to subjects with GSTM1 non-null genotype. Conclusions. GSTM1 null genotype frequency has no role in β-thalassemia or cardiac complications appearance.
Źródło:: Acta Biochimica Polonica; 2016, 63, 2; 267-271
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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