Temat: IL-1β - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Mutual relations between the amygdala and pro-inflammatory cytokines: IL-1β and IL-6
Autorzy:: Czerwiec, Katarzyna
Ruciński, Jan
Piwko, Grzegorz
Myślińska, Dorota
Kosiński, Adam
Powiązania:: https://bibliotekanauki.pl/articles/2203182.pdf
Data publikacji:: 2022-05-31
Wydawca:: Gdański Uniwersytet Medyczny
Tematy:: inflammation
IL-6
amygdala
IL-1β
Opis:: Interleukin 1 (IL-1) and interleukin 6 (IL-6) are typical examples of multfunctonal pro-infammatory cytokines involved in the regulaton of the immune response, hematopoiesis, and infammaton. Both peripheral and intraventricular administraton of these cytokines causes acute phase symptoms, e.g. fever, actvaton of the hypothalamic-pituitary-adrenal axis and psychological depression. The amygdala belongs to the structures of the limbic system involved in the regulaton of the immune response. Increased actvity of immune system may lead to changes in the role of amygdala, medial prefrontal cortex, anterior cingulate cortex or insula. The aim of the study was to present the mutual interactons between the amygdala and pro-infammatory cytokines such as interleukin-1β (IL-1 beta) and interleukin 6 (IL-6). Most of the data included in this review comes from animal studies.
Źródło:: European Journal of Translational and Clinical Medicine; 2022, 5, 1; 40-46
2657-3148
2657-3156
Pojawia się w:: European Journal of Translational and Clinical Medicine
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Limited GADD45α expression and function in IL-1β toxicity towards insulin-producing cells
Autorzy:: Skalniak, Lukasz
Gurgul-Convey, Ewa
Okreglicka, Katarzyna
Skalniak, Anna
Jura, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/1039450.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: GADD45
IL-1β
insulin-producing cells
type 1 diabetes
Opis:: Growth arrest and DNA damage-inducible (GADD) 45 proteins are regulators of cell death and survival. The proinflammatory cytokine IL-1β strongly increases the level of the transcript encoding GADD45α in rat insulin-producing INS-1E cells. The activation of Gadd45α gene is clearly dependent on JNK and NF-κB activation and the synthesis of the secondary mediator nitric oxide (NO). Interestingly, the observed twelve-fold increase in the GADD45α-coding transcript level is not followed by increased expression of GADD45α at the protein level. An analysis of IL-1β toxicity in INS-1E cells overexpressing GADD45α revealed no correlation between the GADD45α protein level and the sensitivity to IL-1β toxicity. These findings suggest that the potential engagement of GADD45α in IL-1β toxicity towards beta cells is limited to the effects induced by the basal expression level of this protein.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 595-602
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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