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Wyszukujesz frazę "Szcześniak, Maria." wg kryterium: Autor

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    Wyświetlanie 1-2 z 2
    Tytuł:
    Physicochemical characterization and dissolution studies of solid dispersions of clotrimazole with chitosan
    Autorzy:
    Grimling, Bożena
    Jasińska, Justyna
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz M.
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034642.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    XRPD
    chitosan
    clotrimazole
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 63-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of a dental formulation prepared with chitosan on the pharmaceutical availability of clotrimazole
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Kocoń, Martyna
    Karolewicz, Bożena
    Złocińska, Adrianna
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034568.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    carrier XRPD
    chitosan
    clotrimazole
    hydrogel
    solid dispersion
    Opis:
    The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two methods: grinding and kneading. The solid dispersion varied the ratio of chitosan to drug to increase the volume of the drug; the ratios were 5:5, 3:7, 2:8, 1:9. The mixtures were subjected to the dissolution rate of clotrimazole. The presence of chitosan improved the drug solubility; a better solubility from the solid dispersion prepared by the grinding method was obtained from the ratio of drug to polymer of 1+9. The rate of dissolution of clotrimazole was improved 17 times compared to the pure drug. Fourier transform infrared spectroscopy (both infrared and X-ray diffraction) revealed no new chemical structure of the tested connections and concluded that there was no interaction between the drug and the polymer in the test diffractions. Solid dispersions with the best parameters were used to prepare hydrogels, and the pharmaceutical availability of clotrimazole was analysed. The best properties were characterized by a hydrogel that was composed of the ratio of the amount of drug to polymer 5:5. The study demonstrated the availability of a pharmaceutical drug release at a therapeutic concentration in the first hour of the study. The use of the appropriate balance between clotrimazole and chitosan and the development of the hydrogel composition may affect the improvement of the drug solubility and may create the possibility of obtaining sustained or controlled release of the drug substance.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 42-53
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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