- Tytuł:
- Binding of the basic fibroblast growth factor (bFGF) by soluble components of human umbilical cord.
- Autorzy:
-
Sobolewski, Krzysztof
Bańkowski, Edward
Pałka, Jerzy
Jaworski, Stefan - Powiązania:
- https://bibliotekanauki.pl/articles/1043707.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
umbilical cord artery
fibroblast growth factor
Wharton's jelly
pre-eclampsia
EPH-gestosis - Opis:
- Pre-eclampsia, the most common pregnancy associated syndrome, is connected with remodelling of extracellular matrix of the umbilical cord tissues. Since the fibroblast growth factor (FGF) is known to be a stimulator of collagen and glycosaminoglycan biosynthesis, one may expect that it plays an important role in such a remodelling. Studies performed on the umbilical cords of 10 control and 10 pre-eclamptic newborns demonstrated that both the umbilical cord arterial wall and Wharton's jelly contain FGF mainly in complexes with the components of different molecular mass. Pre-eclampsia is associated with a decrease of endogenous FGF-binding by soluble high molecular mass components of the umbilical cord. It is suggested that FGF released from these complexes may be actively bound by fibroblasts of the umbilical cord, stimulating them to produce collagen and sulphated glycosaminoglycans.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 4; 999-1004
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł