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    Wyświetlanie 1-4 z 4
    Tytuł:
    PREVELANCE OF METFORMIN-INDUCED GASTROINTESTINAL PROBLEMS
    Autorzy:
    Sadeeqa, Saleha
    Fatima, Madeeha
    Latif, Sumera
    Afzal, Hafsa
    Nazir, Saeed Ur Rashid
    Saeed, Hamid
    Powiązania:
    https://bibliotekanauki.pl/articles/895256.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Diabetes Mellitus
    metformin
    Gastrointestnal
    Opis:
    Metformin is used as an anti-diabetic drug among oral hypoglycemic drugs, which produces many gastrointestinal problems. Study aims to investigate the effect of metformin induced gastrointestinal problems and its prevalence. A cross-sectional study design was adapted using convenience sampling technique, at different Diabetic Centers of Lahore and Faisalabad, Pakistan from, June-2017 to November-2017. A total of 300 male and female patients participated in the study between 26 to 85 years and diagnosed with type-II diabetes. Data was directly collected from the patients and prevalence of metformin-induced gastrointestinal intolerance was determined by the symptoms of the patients. Data was analyzed by SPSS version 21. Results showed a significant difference between gender and symptoms (p=0.029). Moreover, the gastrointestinal problems were found to be dose related. A significant difference existed between patients who were taking 500mg and those taking 850 mg of metformin (p=0.006), patients who were taking 500mg and those taking 1000mg of metformin (p=0.000) and patients who were taking 850mg with those taking 1000mg of metformin (p=0.022). The prevelance of metformin-induced gastrointestinal symptoms was 45.8%. Most commonly occurring symptoms were, constipation (41.35%) followed by dyspepsia (27.89%), abdominal pain (26.92%), bloating and heart burn (25%), indigestion (15.38%), anorexia (11.54%), diarrhea (6.58%), flatulence (7.69%), nausea (6.73%) and vomiting (2.88%). It was concluded that gastrointestinal intolerance was more in females as compared to males. The gastrointestinal problems increased with the increase in dose. The side effects occurred were irrespective of the age and the most common gastrointestinal symptom was found to be constipation.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1073-1077
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Acute cholecystitis in patients with diabetes mellitus - systematic review
    Autorzy:
    Łącka, Monika
    Spychalski, Piotr
    Dobrzycka, Małgorzata
    Rostkowska, Olga
    Kobiela, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/895729.pdf
    Data publikacji:
    2020-01-09
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    complications
    Diabetes Mellitus
    Cholecystitis
    course of hospitalization
    Opis:
    Introduction: According to the WHO, an estimated 422 million people are suffering from diabetes worldwide. Among them, the incidence of cholelithiasis is higher than in the healthy population. The aim of this literature review was to summarize the available evidence about acute cholecystitis in patients with diabetes. Materials and methods: This study adhered to the PRISMA guidelines. The course of hospitalization of patients with and without diabetes who underwent cholecystectomy due to acute cholecystitis was compared. Following information was abstracted from original studies: general study information, patient characteristics, complications, and recommendations for patients with diabetes. Results: Initial search provided 1632 results. After full text assessment, 40 studies met the inclusions criteria. Operative and postoperative complication rates were significantly higher among the diabetic patients. Diabetes is a risk factor for conversion from laparoscopic to open cholecystectomy method. The authors' opinions on elective surgery before the onset of acute cholecystitis symptoms are divided. Conclusions: Diabetic patients are at greater risk of developing complications. An individualized screening and treatment approach, as well as proper preparation of the diabetic patient for an elective cholecystectomy could have a positive effect on the outcome. However, the low quality of the data from the systematic review does not allow for meta-analysis, which is why we cannot draw strong conclusions.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2019, 2, 2; 71-79
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Endocrine disorders in patients with hereditary hemochromatosis
    Autorzy:
    Banaszkiewicz, Katarzyna
    Sikorska, Katarzyna
    Sworczak, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/895739.pdf
    Data publikacji:
    2019-02-05
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    Diabetes Mellitus
    Osteoporosis
    endocrinology
    iron overload
    hemochromatosis
    Opis:
    Hereditary hemochromatosis (HH) is a rare genetic disorder, developing secondary to the accumulation of iron in tissues, which may lead to multiple organ failure. If untreated, it may result in liver cirrhosis or cardiomyopathy. The damage to the pancreas and the anterior pituitary, on the other hand, leads to a decreased production and secretion of hormones that are essential to life. Common symptoms of HH, that are distressing for patients, include joint pain, particularly involving hands and wrists, as well as the chronic fatigue syndrome. Iron overload affects the skeletal system, leading to osteoporosis. The pathological accumulation of iron in the anterior pituitary impairs the gonadotropin synthesis, resulting in reduced serum levels of testosterone in men and estrogens in women. This, however, contributes to lower bone mass. In vivo tests have also revealed that abnormal iron accumulation is related to an increased activity and number of osteoclasts, as well as the influence on the differentiation and activity of osteoblast-lineage cells. Based on a systematic review of literature, hereditary hemochromatosis (HH) will be presented as a chronic disease, affecting most of the endocrine glands.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2018, 1, 2; 72-76
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physical activity in type 2 diabetes mellitus: a review
    Autorzy:
    Burooj, Ahmed
    Powiązania:
    https://bibliotekanauki.pl/articles/33777868.pdf
    Data publikacji:
    2024-04-10
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    T2DM
    Exercise
    Diabetes
    Diabetes Mellitus
    Physical Activity
    Opis:
    Introduction This literature review explores the role of physical activity (PA) in managing and preventing type 2 diabetes mellitus (T2DM), synthesizing the latest guidelines for all T2DM patients. Following PRISMA guidelines, it identifies specific areas for further research. Material and Methods Indexing services (PubMed and Scopus) were used to identify relevant studies, emphasizing original research, review articles, and updated institutional guidelines spanning 2017-2023. The following keywords were used: diabetes, physical activity, type 2 diabetes mellitus, PA, and exercise. Proposal and opinion articles, non-English papers (or those lacking full-text translation), studies involving non-human subjects, pediatric populations or with skewed gender distribution were excluded. Results PA improves quality of life, BMI, glycemic control and well-being. Effects vary by activity domain, such as work or leisure time. Recommendations suggest 60 daily minutes of exercise for children, 150 weekly minutes of moderate intensity exercise for adults, and screening for adverse events. A “sit-less” approach is proposed for those unable to maintain regular activity, with glycemic monitoring for those with variability. Conclusions PA is crucial in T2DM management. Conflicting findings regarding glycemic control warrant further investigation to ascertain causes, whether related to bias or other factors.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2024, 7, 1; 97-105
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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