- Tytuł:
- The bystander effect: is reactive oxygen species the driver?
- Autorzy:
- Szumiel, I.
- Powiązania:
- https://bibliotekanauki.pl/articles/148463.pdf
- Data publikacji:
- 2003
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
bystander effect
reactive oxygen species
ionising radiation
DNA repair
signalling pathways - Opis:
- The paper reviews selected examples of the bystander effect, such as clonogenic survival decrease, chromosomal aberrations and mutations. The similarities and differences between the biological effects in directly targeted and bystander cells are briefly discussed. Also reviewed are the experimental data which support the role of reactive oxygen species (ROS), especially *O2-, as mediators of the bystander effect. Endogenously generated ROS, due to activation of NAD(P)H oxidases, play a key role in the induction of DNA damage in bystander cells. All the observed effects in bystander cells, such as alterations in gene expression patterns, chromosomal aberrations, sister chromatid exchanges, mutations, genome instability, and neoplastic transformation are the consequence of DNA damage.
- Źródło:
-
Nukleonika; 2003, 48, 3; 113-120
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł