- Tytuł:
- New carbocyclic analogues of netropsin: Synthesis and inhibition of topoisomerases.
- Autorzy:
-
Pućkowska, Anna
Bielawski, Krzysztof
Bielawska, Anna
Róański, Andrzej - Powiązania:
- https://bibliotekanauki.pl/articles/1043824.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
topoisomerase inhibition
DNA interaction
lexitropsin
carbocyclic analogues of netropsin - Opis:
- A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topoisomerase I and II assay, the relaxation of pBR322 plasmid was inhibited by compounds 4-7 at 100 μM concentration.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 1; 177-183
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł