- Tytuł:
- Structure and dynamics of a DNA duplex containing single a-anomeric deoxyadenosine residue.
- Autorzy:
-
Bielecki, Łukasz
Adamiak, Ryszard - Powiązania:
- https://bibliotekanauki.pl/articles/1044170.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
structure
base stacking
bending
α-anomers
dynamics
DNA - Opis:
- Structure and dynamics of an undecamer DNA duplex containing a single α-anomeric deoxyadenosine residue placed in opposition to a thymidine unit have been studied using simulation of molecular dynamics in aqueous solution. Despite several noticeable deviations from the B-DNA duplex structure caused by the anomerisation, such as: West type puckering of the α-anomeric sugar, disrupted base stacking pattern and unstable duplex bending, the formation of a non-classical α-dA-T pair was observed. A novel way of visual presentation of trajectory data allowing high throughput screening of the conformational parameters is presented.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 1; 103-111
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł