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    Tytuł:
    The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
    Autorzy:
    Jakubowska, K.
    Pryczynicz, A.
    Dymicka-Piekarska, V.
    Cepowicz, D.
    Jagodzińska, D.
    Lewczuk, Ł.
    Lebelt, A.
    Ozimkiewicz, M.
    Kiszło, P.
    Guzińska-Ustymowicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1917712.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    Growth differentiation factor-15
    macrophage inhibitory cytokine-1
    serum.
    Opis:
    Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
    Źródło:
    Progress in Health Sciences; 2016, 6(1); 40-48
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer
    Autorzy:
    Grudzińska, M.
    Jakubowska, K.
    Kańczuga-Koda, L.
    Kisielewski, W.
    Famulski, W.
    Smereczański, N.M.
    Lomperta, K.
    Płoński, M.A.
    Rogoz-Jezierska, N.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918914.pdf
    Data publikacji:
    2020-06-10
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    inflammatory cells
    fibrosis
    Opis:
    Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
    Źródło:
    Progress in Health Sciences; 2020, 10(1); 69-76
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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