- Tytuł:
- Reduction of bilirubin ditaurate by the intestinal bacterium Clostridium perfringens
- Autorzy:
-
Koníčková, Renata
Jirásková, Alena
Zelenka, Jaroslav
Lešetický, Ladislav
Štícha, Martin
Vítek, Libor - Powiązania:
- https://bibliotekanauki.pl/articles/1039751.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
bilirubin ditaurate
bile pigments
urobilinoids
intestinal metabolism
Clostridium perfringens - Opis:
- Bilirubin is degraded in the human gut by microflora into urobilinoids. In our study we investigated whether the bilirubin-reducing strain of Clostridium perfringens can reduce bilirubin ditaurate (BDT), a bile pigment of some lower vertebrates, without hydrolysis of the taurine moiety. C. perfringes was incubated under anaerobic conditions with BDT; reduction products were quantified by spectrophotometry and separated by TLC. Based on Rf values of BDT reduction products and synthetic urobilinogen ditaurate, three novel taurine-conjugated urobilinoids were identified. It is likely that bilirubin-reducing enzyme(s) serve for the effective disposal of electrons produced by fermentolytic processes in these anaerobic bacteria.
- Źródło:
-
Acta Biochimica Polonica; 2012, 59, 2; 289-292
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł