- Tytuł:
- Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives
- Autorzy:
- Bakare, Safyah B.
- Powiązania:
- https://bibliotekanauki.pl/articles/780055.pdf
- Data publikacji:
- 2019
- Wydawca:
- Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
- Tematy:
-
Thiazole
Anticancer
Cell Cycle Analysis
Annexin V
FITC
Doxorubicin - Opis:
- A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound 4b was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound 4b evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound 4b increased the concentration of caspase 3 by 4 fold more than untreated control.
- Źródło:
-
Polish Journal of Chemical Technology; 2019, 21, 3; 19-25
1509-8117
1899-4741 - Pojawia się w:
- Polish Journal of Chemical Technology
- Dostawca treści:
- Biblioteka Nauki
Artykuł