Temat: CD8+ T cells - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Significant expression of Foxp3 in murine extrathymic CD4+CD8+ double positive T cells
Autorzy:: Gregorczyk, I.
Maślanka, T.
Powiązania:: https://bibliotekanauki.pl/articles/2087878.pdf
Data publikacji:: 2017
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: CD4+CD8+ double-positive (DP) T cells
CD25
Foxp3
Treg cells
mouse
Źródło:: Polish Journal of Veterinary Sciences; 2017, 4; 815-817
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Proliferation and apoptosis of human T cells during replicative senescence - a critical approach.
Autorzy:: Jaruga, Ewa
Skierski, Janusz
Radziszewska, Ewa
Sikora, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/1044352.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: senescence
p16
CD25
apoptosis
T cells
proliferation
CD8
Opis:: Normal human T lymphocytes growing in culture undergo replicative senescence. Previously, we have shown that in our conditions polyclonal T cells cease proliferation after about three weeks (Radziszewska et al., 1999, Cell Biol. Int. 23, 97-103). Now we present results of a more detailed analysis of in vitro growth as well as phenotypic changes of T cells. Cell cycle analysis showed that about 20% of cells were in the S phase untill the 17th day of culture (young cells). The highest number of mitotic cells (phase G2/M; 10%) was observed during the first week of culture. All not dividing senescent cells were stopped in the G1 phase (after the 30th day of culture). The sub-G1 fraction which represents apoptotic cells did not exceed 8% during the whole period until the 30th day of culture. During in vitro T-cell growth, a rather rapid selection to CD3+CD8+ cells occurs. In the presenescent (between the 17th and 30th day) and senescent populations the majority of cells (above 90%) were CD8 positive. We also have checked the expression of α-chain interleukin-2 (IL-2) receptor (CD25). In young and presenescent cells about one third of cells was CD25 positive, but only 15% in the pool of senescent cells. Immunoblotting analysis of p16 protein recognized previously as a marker of senescent T cells, showed its highest and transient expression in presenescent cells. A critical review of the polyclonal T cell replicative senescence model is presented.
Źródło:: Acta Biochimica Polonica; 2000, 47, 2; 293-300
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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