- Tytuł:
- Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.
- Autorzy:
-
Czajkowski, Rafał
Barańska, Jolanta - Powiązania:
- https://bibliotekanauki.pl/articles/1043690.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
ATP
cross-talk
glioma C6 cells
ADP
phospholipase C
nucleotide receptors
adenylyl cyclase
signalling pathways
adenosine - Opis:
- In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 and P2Y12. The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 4; 877-889
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł