- Tytuł:
- DESIGN, SYNTHESIS AND ANALYSIS OF ANTICANCER ACTIVITY OF NEW SAR-BASED S16020 DERIVATIVES
- Autorzy:
-
Tylińska, Beata
Jasztold-Howorko, Ryszard
Kowalczewska, Karina
Szczaurska-Nowak, Katarzyna
Gębarowski, Tomasz
Wietrzyk, Joanna - Powiązania:
- https://bibliotekanauki.pl/articles/895419.pdf
- Data publikacji:
- 2018-12-31
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
A549
cytostatic
olivacine
S16020
NHDF
A498 - Opis:
- A novel set of S16020 derivatives was designed applying structure activity relationships (SAR). The newly synthesized compounds were subjected to in vitro cytostatic activity screening against human kidney cancer (cell line A498), human lung cancer (cell line A549) and normal human dermal fibroblasts (cell line NHDF). Two 6H-pyrido[4,3-b]carbazole derivatives exhibited stronger potency against both investigated cell lines than the reference compounds ellipticine and doxorubicin.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1313-1320
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł