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Wyszukujesz frazę "Fraczek-Szczypta, A." wg kryterium: Autor


Wyświetlanie 1-3 z 3
Tytuł:
Composites for Bone Surgery Based on Micro- and Nanocarbons
Autorzy:
Stodolak, E.
Fraczek-Szczypta, A.
Blazewicz, M.
Blazewicz, S.
Powiązania:
https://bibliotekanauki.pl/articles/1535897.pdf
Data publikacji:
2010-09
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
81.05.Qk
81.05.uj
87.85.jj
87.85.jc
87.17.Ee
Opis:
In this work capabilities of polymer composites modified with carbon materials for application in the bone surgery were compared. The composite materials were produced from synthetic polymer PTFE-PVDF-PP modified with a carbon phase such as: short carbon fibres, carbon nanotubes and carbon fabrics. Determination of mechanical properties of the composite materials indicated that the carbon phase improves strength and Young's modulus of the composite. Moreover, the mechanical parameters can be controlled by the form and amount of the carbon phase introduced into the polymer matrix. Both the fibres and the carbon nanotubes influenced wettability and surface energy of the composites. Also topography of the materials surface was altered, and its roughness was optimal for bone cells (profilometry). Osteoblasts contacted with the polymer-carbon composites showed increased viability comparing with the ones contacting with the pure polymer foil (viability, and cells proliferation: MTT method, concentration of bone protein: viniculine and β-actine). Results of the investigations indicated that the composite materials containing carbon phases are potential materials for repairing of bone tissue damages.
Źródło:
Acta Physica Polonica A; 2010, 118, 3; 450-456
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genotoxicity Study of Carbon Nanoforms using a Comet Assay
Autorzy:
Panek, A.
Frączek-Szczypta, A.
Długoń, E.
Nocuń, M.
Paluszkiewicz, C.
Błażewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/1030655.pdf
Data publikacji:
2018-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.85.jj
87.14.gk
61.48.De
Opis:
Carbon nanoforms due to their unique properties can be applied in many areas also in medicine. This article presents preliminary genotoxicity studies of electrospun carbon nanofibers (ECNF). This material, apart from its numerous applications, may also be a candidate for use in medical therapy and diagnostics. Polyacrylonitrile (PAN) nanofibers received in the electrospinning process were carbonized and thereafter subjected to oxidation treatment (ECNF-F). Both types of fibres were analyzed with regard to genotoxic influence on the fibroblast line cells using comet assay. Additionally, comet assay experiments were conducted on biocompatible carbon nanotubes with a hydrophilic surface. The results indicate the key role of the oxidation process in the functionalization of carbon nanoparticles intended for medical purposes.
Źródło:
Acta Physica Polonica A; 2018, 133, 2; 306-308
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research
Autorzy:
Panek, A.
Błażewicz, M.
Frączek-Szczypta, A.
Adamczyk, J.
Wiltowska-Zuber, J.
Paluszkiewicz, C.
Powiązania:
https://bibliotekanauki.pl/articles/1030633.pdf
Data publikacji:
2018-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.53.-j
87.85.jj
87.14.gk
Opis:
The single cell gel electrophoresis method, known as comet assay, is a rapid and sensitive technique for testing novel chemicals and nanoparticles for genotoxicity, monitoring environmental contamination with genotoxins and human biomonitoring. In our studies we check the applicability of this method for the evaluation of biocompatibility of modified (MWNF) and non-modified multi-walled carbon nanotubes (MWNT) as well as potential genotoxicity of mercury(II) nitrate. The obtained results enabled us to conclude that the presence of Hg(NO₃)₂ (p<0.001) and MWNT (p<0.04) cause a significantly higher level of DNA damage in comparison to functionalised nanomaterials MWNF. It was implied that for the three investigated agents only mercury significantly enhanced genotoxic effect of X-ray exposure (p<0.001) and inhibition of radio-induced DNA damage repair. On the contrary, the presence of MWNF have no influence on cellular repair efficiencies, while incubation with MWNT causes apoptosis and consequently results in lack of attached cells. In conclusion, our results confirmed the genotoxicity of mercury and non-modified carbon nanotubes as well as the biocompatibility of modified nanotubes. Additionally, we proved the usefulness of comet method for the evaluation of genotoxicity and DNA repair under the influence of different compounds and nanomaterials.
Źródło:
Acta Physica Polonica A; 2018, 133, 2; 280-282
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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