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Wyświetlanie 1-2 z 2
Tytuł:
Sulphur XANES Analysis of Cultured Human Prostate Cancer Cells
Autorzy:
Kwiatek, W.
Podgórczyk, M.
Paluszkiewicz, Cz.
Balerna, A.
Kisiel, A.
Powiązania:
https://bibliotekanauki.pl/articles/1812260.pdf
Data publikacji:
2008-08
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.64.kd
87.19.xj
Opis:
Prostate cancer is one of the most commonly diagnosed cancers in men throughout the world. It is believed that changes to the structure of protein binding sites, altering its metabolism, may play an important role in carcinogenesis. Sulphur, often present in binding sites, can influence such changes through its chemical speciation. Hence there is a need for precise investigation of coordination environment of sulphur. X-ray absorption near edge structure spectroscopy offers such possibility. Cell culture samples offer histologically well defined areas of good homogeneity, suitable for successful and reliable X-ray absorption near edge structure analysis. This paper presents sulphur speciation data collected from three different human prostate cancer cell lines (PC-3, LNCaP and DU-145). Sulphur X-ray absorption near edge structure analysis was performed on K-edge structure. The spectra of cells were compared with those of cancerous tissue and with organic substances as well as inorganic compounds.
Źródło:
Acta Physica Polonica A; 2008, 114, 2; 463-470
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of Changes in Sulphur Oxidation States in Prostate Cancer Cells
Autorzy:
Czapla, J.
Kwiatek, W.
Lekki, J.
Steininger, R.
Göttlicher, J.
Powiązania:
https://bibliotekanauki.pl/articles/1490177.pdf
Data publikacji:
2012-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.64.kd
87.19.xj
Opis:
Prostate cancer cell lines along with selected organic and inorganic compounds used as references were studied with sulphur K-edge X-ray absorption near edge structure spectroscopy. The experiment was performed at the SUL-X beamline of the synchrotron radiation source ANKA, Karlsruhe (Germany). The sulphur was chosen for the studies because it is an essential biological element and out of many relevant factors, it is believed that it can take an important part in cancer transformations. The main goal was to determine which sulphur forms occur in prostate cancer cells and to compare these results with the ones obtained for non-cancerous cells. Therefore oxidation state of this element was analysed with S K-edge X-ray absorption near edge structure spectroscopy. The analysis of K-edge structure was done in order to investigate also the chemical structure of the elements neighbouring the central atom. The preliminary results from sulphur X-ray absorption near edge structure in prostate cancer cell line PC-3 and prostatic epithelial cell line PZ-HPV-7 (which was used as a control) show that there are various oxidation states of sulphur occurring in cells. The set of reference compounds with various sulphur oxidation states was used to establish the relation between the energy of the white line maximum and the oxidation state of sulphur. The equation of linear fit was used to compute the unknown oxidation state. In order to obtain a more detailed information the method of deconvolution of X-ray absorption near edge structure spectra was used. Experimental spectra were fitted with two Gaussian peaks and one arctangent step function. Fitting procedure was performed in Athena code and the deconvolution was used to assign the fraction of each sulphur form. The next step was to compare the results calculated for cancerous and non-cancerous cells. In this work, the first results of these studies are presented.
Źródło:
Acta Physica Polonica A; 2012, 121, 2; 497-501
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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