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    Wyświetlanie 1-7 z 7
    Tytuł:
    Investigating Mechanisms of Radiation-Induced DNA Damage Using Low-Energy Photons
    Autorzy:
    Folkard, M.
    Prise, K. M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2044651.pdf
    Data publikacji:
    2006-03
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    Opis:
    Central to any mechanistic biophysical model of radiation damage to DNA is the relationship between the amount and distribution of energy deposited in the DNA helix and the subsequent production of DNA damage. It is now clear from a number of studies that the minimum energy required to produce bond breaks in DNA is significantly lower than might be expected. For example, some biophysical models have assumed that it takes several 10s of eV to produce a double-strand break in DNA. However, using low-energy photons, we have shown that energy depositions as low as 7 eV can induce double-strand break and that this is enhanced when the DNA is hydrated, showing that free radical damage is also important.
    Źródło:
    Acta Physica Polonica A; 2006, 109, 3; 265-271
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Single Proton Hit Facility at the IFJ PAN in Cracow
    Autorzy:
    Polak, W.
    Lekki, J.
    Veselov, O.
    Stachura, Z.
    Styczeń, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2044772.pdf
    Data publikacji:
    2006-03
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.Gi
    87.50.-a
    Opis:
    This work presents the final development stage and optimization results of the single proton hit facility in Cracow. The setup parameters: proton beam energy 2 MeV, hit resolution 30μm, intensity ≈1000 proton/s, proton registration efficiency 100%, blanking efficiency 99.8%. On-line observation allows targeting cells inside a Petri dish mounted at a 3D precise moving stage. To target a particular cell a semiautomatic cell visualization and recognition system is used.
    Źródło:
    Acta Physica Polonica A; 2006, 109, 3; 417-420
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Understanding Radiation Damage to Cells Using Microbeams
    Autorzy:
    Folkard, M.
    Prise, K. M.
    Shao, C.
    Gilchrist, S.
    Schettino, G.
    Michette, A. G.
    Vojnovic, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/2044649.pdf
    Data publikacji:
    2006-03
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    41.75.Ak
    87.50.-a
    Opis:
    Cellular micro-irradiation techniques provide unique experimental opportunities for understanding how ionizing radiation interacts with living cells and tissues. Using microbeams, it is possible to deliver precise doses of radiation to selected individual cells, or sub-cellular targets in vitro. This technique continues to be applied to the investigation of a number of phenomena currently of great interest to the radiobiological community. In particular, it is the study of so-called "non-targeted" effects (where cells are seen to respond indirectly to ionizing radiation) that are benefiting most from the use of microbeam approaches.
    Źródło:
    Acta Physica Polonica A; 2006, 109, 3; 257-264
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The GSI Heavy Ion Microbeam: A Tool for the Investigation of Cellular Response to High LET Radiations
    Autorzy:
    Barberet, Ph.
    Heiss, M.
    Du, G.
    Fischer, B. E.
    Taucher-Scholz, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2044671.pdf
    Data publikacji:
    2006-03
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    41.75.Ak
    87.50.-a
    Opis:
    Since the mid 1990's, an increasing number of charged particle microbeams have been designed to deliver a preset number of ions to individual living cells with the micron resolution. These tools provide a powerful technique to investigate the cellular response to low doses of radiations. During the last years, the single ion hit facility in operation on the GSI microbeam since 1987 has been upgraded for the irradiation of individual living cells in vitro. This setup presents two main peculiarities compared to the microbeams used up to now for cell irradiation. First, the beam's micrometric size is obtained by magnetic focusing and not by a simple collimation. This allows obtaining a smaller beam spot, a better defined linear energy transfer, and a high irradiation throughput. Then, the GSI microbeam is able to focus ions from carbon to uranium with energies between 1.4 MeV/u to 11.4 MeV/u. The range of accessible linear energy transfer is thus considerably extended compared to light ions microbeam in operation today. The design of the GSI microbeam is described, including the beam control, the online cell localisation, the cell dish designed specifically for microbeam irradiation, and the cell irradiation procedures. Experimental tests performed to check the global aiming accuracy as well as the first cellular irradiations are presented.
    Źródło:
    Acta Physica Polonica A; 2006, 109, 3; 329-334
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of 60 MeV Protons and 250 kV X-Rays on Cell Viability
    Autorzy:
    Miszczyk, J.
    Panek, A.
    Rawojć, K.
    Swakoń, J.
    Prasanna, P.
    Rydygier, M.
    Gałaś, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1398817.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    87.53.-j
    87.53.Bn
    Opis:
    Particle radiotherapy such as the one using proton beams, provides a successful treatment approach in many cancer types. However, the cellular and molecular mechanisms by which proton irradiation induces cell death, particularly in a human peripheral blood lymphocyte model has not been examined in detail. Comparative studies of the biological effects, such as cell death, of particle therapy versus conventional X-rays treatment are of utmost importance. Here, we compared the viability of human peripheral blood lymphocyte following in vitro irradiation with protons (therapeutic 60 MeV proton beam) and photon beam (250 kV, X-rays), by applying separate doses within the range of 0.3-4.0 Gy. Cell viability was assessed 1 and 4 h after irradiation with protons and X-rays by the FITC-Annexin V labelling procedure (Apoptotic & Necrotic & Healthy Cells Quantification Kit, Biotium). Results showed that irradiation with both radiation types reduced the number of viable cells in a dose-dependent manner, as assessed as a function of the duration of post-irradiation time. Protons proved more fatal to the cells treated than X-ray photons. This demonstrates a difference in cell viability after irradiation with protons and photons in a human peripheral blood lymphocyte model.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 222-225
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of Pulsed High-Voltage Stimulation οn Pholiota Nameko Mushroom Yield
    Autorzy:
    Takaki, K.
    Yamazaki, N.
    Mukaigawa, S.
    Fujiwara, T.
    Kofujita, H.
    Takahasi, K.
    Narimatsu, M.
    Nagane, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1807916.pdf
    Data publikacji:
    2009-06
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    52.90.+z
    82.39.Rt
    Opis:
    A pulsed high voltage was applied to logs for mushroom cultivation to investigate an effect of pulse high voltage on mushroom growth. Inductive energy storage system was utilized to construct a pulsed power generator with compact size. Copper fuse of 0.03 mm diameter was used as an opening switch to interrupt large circuit current in short time. The voltage charged in primary energy storage capacitor was multiplied using secondary energy storage inductor. The output voltage of the pulsed power generator was 120 kV with 100 ns pulse width at 14 kV charging voltage of 0.22 μF primary energy storage capacitor and 15 μH secondary energy storage inductor. This pulsed high voltage was applied to 90 cm length logs inoculated Pholiota nameko fungus. The yield of Pholiota nameko mushrooms was successfully improved with the pulse voltage stimulation. The total weight of the cropped Pholiota nameko after the pulse voltage stimulation was 6.3 kg for fifteen logs and this value was 1.5 times larger than 4.3 kg of total weight without the stimulation. The number of logs with lower than 0.27 kg cropped Pholiota nameko weight which was an average value for control group was only one in fifteen, whereas four logs in control group showed almost zero weight of cropped Pholiota nameko.
    Źródło:
    Acta Physica Polonica A; 2009, 115, 6; 1062-1065
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of magnetite composite on the amount of double strand breaks induced with X-rays
    Autorzy:
    Wiecheć, A.
    Nowicka, K.
    Błażewicz, M.
    Kwiatek, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1065182.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    87.53.-j
    81.05.Mh
    81.05.Ni
    81.05.Pj
    81.05.Qk
    75.50.Bb
    Opis:
    The aim of this study was to find out if polylactide (PLA) modified with magnetite might affect the amount of DNA double strand breaks induced with X-rays. The human osteosarcoma cells (MG63) were seeded on the polystyrene cell culture dishes (PS), PLA and PLA modified with magnetite substrates. The double strand breaks were analyzed after X-ray irradiation (dose rate 2 Gy/min), in the first day of culturing. The number of double strand breaks increased in the PLA modified with magnetite, for example after 1 Gy of X-rays irradiation, double strand breaks/cell equaled: 24.5 vs. 17.5 and 17.3, for PLA modified with magnetite vs. PLA and PS, p < 0.0003. We conclude that PLA modified with magnetite changed the number of double strand breaks induced with X-rays. However, more research is needed to confirm that such composite might be considered as radiosensitizer in radiotherapy.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 174-175
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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