- Tytuł:
- Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI
- Autorzy:
-
Strbak, O.
Kubovcikova, M.
Baciak, L.
Khmara, I.
Gogola, D.
Koneracka, M.
Zavisova, V.
Antal, I.
Masarova, M.
Krafcik, A.
Kopcansky, P.
Dobrota, D.
Frollo, I. - Powiązania:
- https://bibliotekanauki.pl/articles/1032224.pdf
- Data publikacji:
- 2017-04
- Wydawca:
- Polska Akademia Nauk. Instytut Fizyki PAN
- Tematy:
-
87.61.-c
75.75.Fk
87.15.kp - Opis:
- The aim of the study was to establish whether there is a significant change in the MRI contrast of magnetite nanoparticles, after BSA protein binding on the surface of particles. The rationale is the applicability of this feature in clinical practice for the tracking of specific proteins which are often associated with various pathologies. Contrast agents could bind to this specific marker, with the change in MRI contrast indicating the presence of pathology. We found that changes in relative contrast acquired at low-field MRI offer potential for the differentiation of magnetite nanoparticles with and without BSA protein. However, the variations in the transverse relaxation time (T₂) and transverse relaxivity (r₂), acquired at high-field MRI, were too small to be applicable for biomedical applications.
- Źródło:
-
Acta Physica Polonica A; 2017, 131, 4; 1102-1104
0587-4246
1898-794X - Pojawia się w:
- Acta Physica Polonica A
- Dostawca treści:
- Biblioteka Nauki
Artykuł