- Tytuł:
- Menadione effect on l-cysteine desulfuration in U373 cells
- Autorzy:
-
Wróbel, Maria
Jurkowska, Halina - Powiązania:
- https://bibliotekanauki.pl/articles/1041097.pdf
- Data publikacji:
- 2007
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
menadione
astrocytoma U373
sulfane sulfur
3-mercaptopyruvate sulfurtransferase
reactive oxygen species
rhodanese - Opis:
- The non-cytotoxic concentration (20 µM) of menadione (2-methyl-1,4-naphthoquinone), after 1 h of incubation, leads to loss of the activity of rhodanese by 33%, 3-mercaptopyruvate sulfurtransferase by 20%, as well as the level of sulfane sulfur by about 23% and glutathione by 12%, in the culture of U373 cells, in comparison with the control culture. Reactive oxygen species generated by menadione oxidize sulfhydryl groups in active centers of the investigated enzymes, inhibiting them and saving cysteine for glutathione synthesis. A decreased sulfane sulfur level can be correlated with an oxidative stress.
- Źródło:
-
Acta Biochimica Polonica; 2007, 54, 2; 407-411
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł