- Tytuł:
-
Syntezy wybranych, nowych pochodnych 2-amino-1H-benzimidazolu i ich mechanizmy działania biologicznego
Synthesis of Selected, New 2-amino-1H-benzimidazole derivatives and Their mechanism of biological activity - Autorzy:
-
Nowicka, A.
Nawrocka, W. P. - Powiązania:
- https://bibliotekanauki.pl/articles/172102.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
pochodne 2-amino-1H-benzimidazolu
syntezy
aktywność biologiczna
2-amino-1H-benzimidazole derivatives
synthesis
biological activity - Opis:
- Many 2-amino-1H-benzimidazole drugs such as antihistaminic mizolastine and norastemizole or antiparasitic mebendazole, albendazole and thiabendazole have been used in clinic [1, 2]. Benomyl and its metabolite Carbendazim are both antifungal and anticancer drugs [4]. Recently, a lot of literature has revealed that 2-amino-1H-benzimidazole derivatives could effectively inhibit the growth of various microorganisms, what suggests that 2-aminobenzimidazole compounds should have large potential as a new type of antibacterial [15] and antifungal [18] agents. A number of 2-aminobenzimidazoles have exhibited antiproliferative in vitro properties [11]. Some new compounds, containing in theirs structures 2-aminobenzimidazole, show interesting and diverse cytotoxic mechanism of action, e.g. induce apoptosis of cancer cells [13]. Some of 2-aminobenzimidazole analogues are histamine and serotonin receptors antagonists [32]. 2-Aminobenzimidazoles derivatives have been frequently found to display a variety of biological activities like anti-inflammatory, antioxidant and anticoagulant [32] properties.
- Źródło:
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Wiadomości Chemiczne; 2013, 67, 3-4; 203-225
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł