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Wyszukujesz frazę "genistein" wg kryterium: Wszystkie pola

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    Wyświetlanie 1-2 z 2
    Tytuł:
    Encapsulation of genistein in glycidylated G3 polyamidoamine dendrimers enables diffusion of genistein through biological membranes and anti-nematode activity of the encapsulate
    Autorzy:
    Filipowicz-Rachwał, Aleksandra
    Drozdowska, Joanna
    Zagórska-Dziok, Martyna
    Uram, Łukasz
    Wołowiec, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/40556674.pdf
    Data publikacji:
    2024-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    C. elegans
    fibroblast BJ toxicity
    genistein
    keratinocyte HaCaT toxicity
    PAMAM dendrimer
    Opis:
    Introduction and aim. Poorly soluble isoflavonoid genistein is known as an anti-nematode agent and also it decreases the risk of certain types of cancer. The biological activity of genistein is limited mostly by its low solubility. Therefore many attempts to increase genistein solubility in water were reported. We applied a polyamidoamine dendrimer, modified its surface by glycidylation, and used this macromolecule as a guest for genistein. Material and methods. Polyamidoamine dendrimer 3rd generation was substituted with 64 glycidol residues to obtain a macromolecule host for genistein. The stoichiometry of this host-guest complex was determined. The complex was tested for skin model permeability, toxicity on fibroblast (BJ) and keratinocyte (HaCaT) cell lines in vitro and anthelmintic activity on the Caenorhabditis elegans nematode. Results. The partition coefficient of genistein between octanol and water was determined (KO/W). The 1:1 host-guest complex was isolated and used as drug delivery system for genistein delivery. PAMAM G3 glycidyled dendrimer containing genistein indicated an anthelmintic activity at 50 μM concentration. Conclusion. The solubility of genistein in water increases 640 times in presence of an equimolar concentration of the dendrimer. One molecule of host dendrimer encapsulates 3 molecules of genistein. The encapsulate is an efficient anti-nematode formulation.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 292-299
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An in vitro study for the evaluation of morphological and biochemical characteristics of absorbable sutures coated with genistein and nicotine
    Autorzy:
    Chopra, Aditi
    Cecil, Anju
    Eshwaramoorthy, Rajalaksmanan
    John, Rubin S.
    Powiązania:
    https://bibliotekanauki.pl/articles/29520461.pdf
    Data publikacji:
    2023-12-31
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    absorbable sutures
    antiinflammatory
    antioxidant
    genistein
    nicotine
    tensile strength
    Opis:
    Introduction and aim. Inflammation, cell proliferation, matrix deposition, and tissue remodeling are all elements of the well-structured and well-coordinated process of wound repair. The aim of this study was to analyze the effect of genistein and nicotine on polyglycolic acid (PGA) and vicryl sutures. Material and methods. Genistein and nicotine were isolated and solution was prepared and the suture material PGA and vicryl were immersed in the solution and dried. They were tested for their tensile strength and degradation values after immersion in artificial saliva (on the first day and on the 14th day). The sutures were also seen under a scanning electron microscope (SEM) for its uniform coating and the mixture formulation of genistein and nicotine were tested for their anti-inflammatory and antioxidant activity using protein denaturation assay and 2,2-diphenyl-1-picrylhydrazyl assay respectively. Results. Nicotine has a high anti-inflammatory activity on the suture material, whereas Genistein has an insignificant anti-inflammatory effect. The mixture formulation has a relatively similar anti-inflammatory effect when compared to the control. The SEM analysis shows a uniform coating of the formulation on the PGA and vicryl sutures. In comparison, PGA has shown lesser tensile strength and hence higher degradation ability. Conclusion. Nicotine and Genistein affect the tensile strength and degradation properties of the sutures.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 4; 742-749
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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