- Tytuł:
- Effect of a medicinal agent, possessing antioxidant and antihypoxant properties, on the state of oxygen homeostasis and lipid peroxidation under experimental pneumoconiosis in albino rats
- Autorzy:
-
Olyinyk, A.
Ślifirczyk, A.
Nikoniuk, M.
Celiński, M.
Domańska, D. - Powiązania:
- https://bibliotekanauki.pl/articles/1918832.pdf
- Data publikacji:
- 2018
- Wydawca:
- Uniwersytet Medyczny w Białymstoku
- Tematy:
-
experimental pneumoconiosis
metho-dology of pneumoconiosis stimulation in albino rats
lipid peroxidation
oxygen metabolism
ethylmethylhydroxypyridine succinate - Opis:
- Introduction: Pneumoconioses (Pc) are interstitial pulmonary diseases of professional genesis, caused by long-term inhalation of high dust concentrations. Pcafflict 26.6-53% of the workers, exposed to dust contamination. The major feature of Pc course is irrevocability and incurability. Purpose: The research of the effect of ethylmethyl hydroxypyridine succinate, possessing antioxidant and antihypoxant characteristics, on the oxygen metabolism, acid-alkaline state, and lipid peroxidation at the background of experimental pneumoconiosis in albino rats. Material and methods: Pneumoconiosis was simulated on 72 albino rats through endotracheal injection of black coal suspension, on our own modification of O. Yu. Nykolenko methodology. Results: Manifestations of experimental pneumo-coniosis depended on the period of dust inhalation. Development of experimental pneumoconiosis was found to result in the decreased partial oxygen pressure in the arterial blood, compensated hyperventilation-induced respiratory alkalosis, and marked increase in lipid peroxidation activity that could be seen in the blood content of malon-dialdehyde, as well as of conjugated dienes and trienes. Conclusions: Application of ethylmethylhydroxy pyridine succinate in experimental pneumoconiosis has been found to improve oxygen metabolism, acid-alkaline state, and lipid peroxidation that is revealed in normalization of the partial oxygen pressure in the arterial blood, oxygen saturation of haemoglobin, index of bases’ deficiency BE (Ваse-Ехсеss), and in 1.6-2.0 decrease in the content of malondialdehyde, as well as of conjugated dienes and trienes.
- Źródło:
-
Progress in Health Sciences; 2018, 8(2); 137-143
2083-1617 - Pojawia się w:
- Progress in Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł