- Tytuł:
- Antinociceptive effect of poneratoxin [PoTX] in rats
- Autorzy:
-
Rykaczewska-Czerwinska, M.
Radosz, A.
Konopinska, D.
Wrobel, M.
Plech, A. - Powiązania:
- https://bibliotekanauki.pl/articles/55195.pdf
- Data publikacji:
- 2008
- Wydawca:
- Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
- Tematy:
-
isolation
tail immersion test
analgetic effect
rat
ant
amino acid
poneratoxin
venom
neuropeptide - Opis:
- Poneratoxin (molecular weight 2932) is a 25 amino acid neuropeptide, isolated from an ant venom. It affects excitability of nerve and muscle fibres by changing the kinetics of the voltage-dependent sodium channel. The aim of the study was to investigate the analgetic effect of synthetic poneratoxin (PoTX) in adult female Wistar rats. In the first part of the study the animals received PoTX intracerebroventricularly. The analgetic effect was evaluated by a tail immersion test. In the second part of the experiment the analgetic effect of PoTX was blocked with naloxone, an opioid receptors antagonist. The study showed that poneratoxin exerts the analgetic effect in rats and this effect is not mediated by central opioid system. Therefore it was concluded that other mechanism is resposible for the effect of PoTX.
- Źródło:
-
Pestycydy; 2008, 1-2; 135-141
0208-8703 - Pojawia się w:
- Pestycydy
- Dostawca treści:
- Biblioteka Nauki
Artykuł