- Tytuł:
- AGEs interactions with RAGE and their contribution to diabetic retinopathy
- Autorzy:
-
Solan, Anna
Kempka, Katarzyna
Kamiński, Piotr
Bogdzińska, Maria
Malukiewicz, Grażyna - Powiązania:
- https://bibliotekanauki.pl/articles/1075668.pdf
- Data publikacji:
- 2019
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
RAGE
diabetic retinopathy
molecular basis
polimorphism
signaling pathway - Opis:
- Diabetic retinopathy as a complication of diabetes is one of the most common causes of vision loss. It is a dangerous disease, which affects more and more people. It is important to know its different causes, background and to generate new, effective therapeutic threatments. One of the possible causes of diabetic retinopathy is the accumulation of advanced glycation products and over-expression of AGEs receptors (RAGE) leading to tissue damage, oxidative stress formation, and the promotion of other changes and disorders. There are many genetic variants that encode the AGEs receptor (RAGE). Some polymorphisms (Gly82Ser, 1704G/T, 2184A/G, -429T/C, -374T/A) may be associated with diabetic retinopathy. This paper aims to systematize knowledge in this field and to show the relationship between these compounds and diabetic retinopathy.
- Źródło:
-
World Scientific News; 2019, 119; 41-51
2392-2192 - Pojawia się w:
- World Scientific News
- Dostawca treści:
- Biblioteka Nauki
Artykuł