- Tytuł:
- Synthesis and pharmacokinetic study of new thiazole derivatives containing pyrazole moiety
- Autorzy:
-
Namera, Dipti L.
Bhoya, Umed C.
Shah, Anamik K. - Powiązania:
- https://bibliotekanauki.pl/articles/1068636.pdf
- Data publikacji:
- 2019
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
Microwave irradiation
Pharmacokinetic
Pyrazole
Thiazole
eco-friendly - Opis:
- For developed new eco-friendly synthetic route for the synthesis of organic compounds, here in, we have synthesized new series of thiazole derivatives 7(a-h) under microwave irradiation method using less amount of methanol as solvent and less hazardous K2CO3 as catalyst. Then after for the pharmacokinetic study, we can calculate Lipinski rules of five data using swiss ADME software, molecule 7f was fitted in ‘rules of five’ (Ro5) other compounds are showed violence in log P(o/w). The structures of all synthesized compounds are well characterized by Mass, 1H NMR, 13C NMR.
- Źródło:
-
World Scientific News; 2019, 132; 277-284
2392-2192 - Pojawia się w:
- World Scientific News
- Dostawca treści:
- Biblioteka Nauki
Artykuł