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    Wyświetlanie 1-4 z 4
    Tytuł:
    Macrophages in Diabetes Mellitus: A Review on Understanding of Macrophage Function
    Autorzy:
    Chatterjee, Susraba
    Guria, Srikanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1059398.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Alloxan
    Beta-cell Therapy
    Cytokines
    Diabetes mellitus
    Diabetic Nephropathy
    Diabetic Retinopathy
    Macrophage
    Macrophage Type 1
    Macrophage Type 2
    Streptozotocin
    Opis:
    Diabetes mellitus (DM) causes millions of deaths all over the world. Immune system contains macrophages that play very important role in DM. Excessive secretion of different cytokines can induce the DM development. Diabetes mellitus (DM) also affect the function of macrophage. We review the important findings regarding the role of macrophage in DM. This review may emphasize future direction towards development of novel immune-modulatory therapeutic intervention.
    Źródło:
    World Scientific News; 2019, 134, 2; 319-325
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effectiveness of electrical stimulation and low-intensity laser therapy on diabetic neuropathy: A systematic review
    Autorzy:
    Adehunoluwa, Emmanuel A.
    Adesina, Miracle A.
    Adeulure, Taiwo G.
    Akinfolarin, Yemi T.
    Babatunde, Kazeem O.
    Efunniyi, Adenike O.
    Mamud, Olusola S.
    Oyejola, Oluwatimilehin G.
    Tiamiyu, Oluwaleke M.
    Olajire, Tolulope I.
    Powiązania:
    https://bibliotekanauki.pl/articles/1077040.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Diabetes mellitus
    diabetic neuropathy
    electric stimulation
    laser therapy
    Opis:
    Diabetes mellitus (DM) is a group of metabolic diseases which typically presents with frequent urination, increased thirst and increased hunger. DM be classified into three main types: type I (insulin-dependent DM), type-II (non-insulin dependent DM) and type III (gestational DM). Diabetes is a group of diseases of global health significance as 382 million people worldwide had diabetes in the year 2013 and this was projected to increase to an estimated 415 million in 2015. Damage to the nerves of the body (diabetic neuropathy) is the most common complication of diabetes. The signs and symptoms of diabetic neuropathy include numbness, diminished sensation, pain etc. Various types of electrotherapy, such as transcutaneous electrical nerve stimulation (TENS), pulsed-dose electrical stimulation, frequency-modulated electromagnetic neural stimulation, have been reported effective in managing diabetic neuropathy. This study is a systematic review of the evidence to enable the determination of the effectiveness of electrical stimulation and low-intensity laser therapy (LILT), and also aid their recommendation if proven to be effective. The outcome of this study was that TENS and other forms of electrical stimulation reviewed in this study may be effective and safe non-pharmacological treatment modalities in relieving the symptoms associated with diabetic neuropathy. The effectiveness of LILT couldn’t be determined due to the different parameters used to evaluate patients’ outcome and limited number of studies. Authors recommend that further randomized controlled trials with similar methodological parameters and studies with higher quality of evidences are needed to establish the true effectiveness of these modalities in diabetic neuropathy.
    Źródło:
    World News of Natural Sciences; 2019, 23; 110-127
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    AGEs interactions with RAGE and their contribution to diabetic retinopathy
    Autorzy:
    Solan, Anna
    Kempka, Katarzyna
    Kamiński, Piotr
    Bogdzińska, Maria
    Malukiewicz, Grażyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1075668.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    RAGE
    diabetic retinopathy
    molecular basis
    polimorphism
    signaling pathway
    Opis:
    Diabetic retinopathy as a complication of diabetes is one of the most common causes of vision loss. It is a dangerous disease, which affects more and more people. It is important to know its different causes, background and to generate new, effective therapeutic threatments. One of the possible causes of diabetic retinopathy is the accumulation of advanced glycation products and over-expression of AGEs receptors (RAGE) leading to tissue damage, oxidative stress formation, and the promotion of other changes and disorders. There are many genetic variants that encode the AGEs receptor (RAGE). Some polymorphisms (Gly82Ser, 1704G/T, 2184A/G, -429T/C, -374T/A) may be associated with diabetic retinopathy. This paper aims to systematize knowledge in this field and to show the relationship between these compounds and diabetic retinopathy.
    Źródło:
    World Scientific News; 2019, 119; 41-51
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Intranasal insulin and cell-penetrating peptides in the treatment of Alzheimer’s disease
    Autorzy:
    Marciniec, Michał
    Kulczyński, Marcin
    Nowak, Andrzej
    Kwak, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1178799.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Alzheimer's disease
    GLP-1 agonists
    anti-diabetic drugs
    cell-penetrating peptides
    cognitive function
    dementia
    intranasal insulin
    Opis:
    Alzheimer’s disease (AD) is the most common cause of dementia and is responsible for up to 75% of the nearly 47 million dementia cases worldwide. AD is the clinical manifestation of toxic β-amyloid and neurofibrillary tangles accumulation caused by altered proteostasis. Due to not fully understood molecular mechanisms of AD only symptomatic treatment is available. Considering that cognitive decline is associated with insulin resistance, metabolic alterations may be the primary causes of the AD and insulin therapy is proposed as a novel approach in AD treatment. Intranasal administration of insulin appears to be a profitable solution for drug delivery to the brain due to blood-brain barrier bypassing, higher bioavailability and the lack of systemic side effects. When applying this method, insulin is sprayed into the nasal cavity, enters the mucosa and is transported along the axon bundles to the brain. Clinical trials of AD treatment with intranasal insulin revealed improvement in cognition, verbal memory and functional status. Notably, enhancement in memory and cognition were observed both in healthy adults and in AD patients and were ApoE ε4-related. The use of cell-penetrating peptides (CPPs) improve cellular uptake of insulin, enhance bioavailability and increase the direct insulin transport into the deeper regions of the brain such as the olfactory bulb and hippocampus. Animal studies revealed beneficial effects on AD symptoms of other molecules applied in connection with CPPs and most of them approve CPPs formulations for use in clinical trials. This review article summarize clinical trials results of intranasal insulin administration in AD treatment and propose the use of CPPs as an additive to conventional and experimental therapies for AD.
    Źródło:
    World Scientific News; 2017, 90; 138-149
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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