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    Wyświetlanie 1-6 z 6
    Tytuł:
    Extrapulmonary tuberculosis: An overview on infection beyond Lungs
    Autorzy:
    Khusro, Ameer
    Aarti, Chirom
    Powiązania:
    https://bibliotekanauki.pl/articles/1031696.pdf
    Data publikacji:
    2020
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Clinical monitoring
    Extrapulmonary tuberculosis
    Organs
    Tissues
    Tuberculosis
    Opis:
    Extrapulmonary tuberculosis (EPTB) involves 10-15% of all tuberculosis (TB) cases. Recent statistical report showed that EPTB accounts for more than 50% of all cases of TB in HIV-positive patients. In spite of existing anti-tubercular drugs based treatment of EPTB, the ideal regimen and duration of treatment have not yet been established. In general, EPTB is a kind of TB infecting diversified tissues and organs of body other than lungs. In fact, people suffering from TB and co-infected with HIV are prone to develop EPTB much more frequently. The present chapter discusses on the general overviews of EPTB infecting distinct body sites other than lungs. Currently, the treatment of EPTB completely relies on existing anti-tubercular drugs. In addition, significant efforts, particularly close clinical monitoring would be an imperative step towards its therapeutic strategy.
    Źródło:
    World News of Natural Sciences; 2020, 28; 131-141
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antimycobacterial activity of ethanolic extract of Artemisia absinthium L.
    Autorzy:
    Hojageldiyev, T.
    Bolmammedov, Y.
    Gurbanaliyev, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/1075710.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Artemisia absinthium
    Mycobacteria tuberculosis
    Mycobacterium tuberculosis
    antimycobacterial
    ethanolic extract
    Opis:
    It is known that, drugs used in the treatment of tuberculosis show toxic effect to organism especially to liver beside its therapeutic effect. Because of ineffectiveness of drugs used in the treatment regimen of tuberculosis against multidrug resistance (MDR) and extensively drug-resistance (XDR) tuberculosis requires the development of new treatment methods and new novel drugs. Considering the usage of Artemisia absinthium in traditional medicine in treatment of wounds which suggests its antibacterial activity it seems that, also it may have significant antimycobacterial activity. The objective of present study was to evaluate antibacterial activity of ethanolic extract of A. absinthium against M. tuberculosis. In this study, the effect of ethanolic extract of A. absinthium was tested against tuberculosis and pharmaco-toxicological properties evaluated on laboratory animals. The 20%, 40%, 70% and 96% ethanolic extracts of A. absinthium prepared then its bacteriostatic and bactericidal activities were evaluated by validated methods. Data were analyzed by GraphPad Prism 7.0 at the level P<0.05. Results showed that ethanolic extracts of A. absinthium show no toxicological properties with having high LD50. All concentrations of extract show high bacteriostatic activity on M. tuberculosis. 96% ethanolic extract has highest bactericidal effect among other concentrations. By conducting further studies, as a results of our study, antimycobacterial drug can be prepared from A. absinthium.
    Źródło:
    World Scientific News; 2019, 119; 224-230
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lymphoma co existing with Tuberculosis granulomatous
    Autorzy:
    Subhan, Madeeha
    Sadiq, Waleed
    Powiązania:
    https://bibliotekanauki.pl/articles/1178816.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Hodgkin
    Tuberculosis granulomatous
    cervical
    lymphoma
    Opis:
    Hodgkin lymphoma is malignant condition with good prognosis. Asymptomatic lymphadenopathy is a manifestation with cervical, supraclavicular and mediastinal lymph nodes.
    Źródło:
    World Scientific News; 2017, 90; 265-270
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Health Education and Information: a Panacea to Tuberculosis Prevention and Eradication in Nigeria
    Autorzy:
    Fasoranti, Afolabi Joseph
    Powiązania:
    https://bibliotekanauki.pl/articles/1182892.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    health education
    tuberculosis
    eradication
    communicable diseases
    nigeria
    Opis:
    Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis. Tuberculosis is a major public health problem in Nigeria, being one of the ten leading causes of hospital admissions and a leading cause of death in adults, especially among the economically productive age group. This paper critically examined the importance of health education towards the eradication and prevention of tuberculosis in Nigeria. It was reviewed and discussed under the following subheadings; Global burden of tuberculosis in Nigeria, concept, definition and etiology of tuberculosis Signs and symptoms of tuberculosis, diagnosis of tuberculosis, causative agent, modes of infection and incubation period, risk factors of pulmonary tuberculosis Dots and stop TB programmes in Nigeria Treatment and prevention of tuberculosis TB treatment strategies Dealing with treatment problems in Nigeria Stigmatization against Tuberculosis Patients Health education as a tool for achieving free tuberculosis country. Emphasis for Tb control has been placed on the development of improved vaccines, diagnostic and treatment courses but less on health education and awareness. Although the need for theses tools is indisputable, the obstacle facing the spread of TB go beyond technological. The findings of this study may stimulate health system policy makers, Government and non- governmental organizations, donor agencies amd other stakeholders in planning and designing health education intervention programmes on the control and eradication of tuberculosis. It therefore recommended that Government should implement health education as part of the DOTs, this will thus empower the tuberculosis patients on ways to live healthy, lifestyle, in doing this, they will recover fastly and prevent them from spreading the disease.
    Źródło:
    World Scientific News; 2016, 53, 3; 323-342
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Air transport and the spread of infectious diseases
    Autorzy:
    Kulczyński, Marcin
    Tomaszewski, Mateusz
    Łuniewski, Michał
    Olender, Alina
    Powiązania:
    https://bibliotekanauki.pl/articles/1179535.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    MERS
    West Nile Virus
    air transport
    aircraft
    airport
    aviation
    infectious diseases
    influenza
    pandemic
    tuberculosis
    Opis:
    Dynamically growing number of airline passengers and flights, especially intercontinental ones, is a key factor conducive to the spread of infectious diseases. The threat to public health may be even more noticeable if it is taken into account, that the developing countries record larger increase in air traffic than most European high developed states with good sanitary conditions. The aim of the study is to make a review of the literature concerning risk assessment and ways to prevent transmission of infectious diseases aboard civil aircrafts. Airline-associated spread of infectious diseases can refer to airborne and vector-borne diseases, as well as these transmitted by fecal-oral route. The particular danger of rapid spread of a disease through airline passengers is caused by influenza virus strains with the potential for causing pandemics or coronaviruses that are infectious agents of MERS and SARS. Passengers suffering from active tuberculosis are also a reason of a serious epidemiological concern. Also other airborne diseases like measles can be easily transmitted by air transport when travelling from endemic countries. On the other hand, flight-related food poisonings are less and less frequent – the most common cause are still bacteria of the Salmonella genus. Among vector-borne diseases, particular attention is paid to the problem of possible transfer of mosquitoes infected with West Nile Virus. In the prevention of the spread of communicable diseases via air transport, there are important factors such as: efficient identifying of sick travellers and crew members, use of personal protective equipment (such as masks with HEPA filter) by passengers travelling alongside sick person, efficient ventilation inside the passenger cabin, proper disinfection of aircrafts' interiors, vaccination of cabin crews against influenza and proper preparation and handling of catering provided to aircrafts.
    Źródło:
    World Scientific News; 2017, 76; 123-135
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Docking for drug interface residues of modelled VPS33B of human with PtpA of Mycobacterium tuberculosis CDC1551
    Autorzy:
    Reddy, K.M.
    Pattathil, M.D.
    Jayachandra, S.Y.
    Parameshwar, A.
    Sulochana, M.B.
    Powiązania:
    https://bibliotekanauki.pl/articles/11443.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    antigenicity
    protein-protein interaction
    network
    homology modelling
    drug design
    interface residue
    Mycobacterium tuberculosis
    man
    protein
    biological function
    Opis:
    VPS33B, a human Vacuolar Protein Sorting (VPS) protein which mediates the phagolysosomal fusion in macrophage of the eukaryotic organisms. This protein has a great role during the mycobacterial infections, which binds with the Mycobacterium protein tyrosine phosphatase A (PtpA). A single functional domain of PtpA has been identified using SMART domain databases, followed by finding the antigenicity of PtpA using CLC main workbench tool. The protein-protein interaction network predicts the interface of biological functions of proteins, built by using Cytoscape 2.8.3 version tool for manual literature survey of protein sets. According to the literature the specific interactivity of PtpA with VPS33B of human lead to pathogenesis, and provided a good platform to find the structure of VPS33B as it lacks the 3 dimensional structure in PDB. Homology Modelling of VPS33B provides a significant properties to design a specific drug through screening the drug databases (eDrug3D). The modelled protein has been validated through SAVES server maintained by NIH and UCLA with the standard Ramachandran plot with accuracy of 90.7 %. From our findings the interface residues are very crucial points which has been found through docking the modelled protein and Mycobacterium protein and interface residues were selected manually using PyMol software.
    Źródło:
    International Letters of Natural Sciences; 2014, 11, 2
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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