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    Wyświetlanie 1-7 z 7
    Tytuł:
    Risk associated with heavy metals in children playground soils of Owerri metropolis, Imo State, Nigeria
    Autorzy:
    Wirnkor, Verla Andrew
    Evelyn Ngozi, Verla Evelyn
    Powiązania:
    https://bibliotekanauki.pl/articles/1118068.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Bioconcentration
    Metal fractions
    Models
    Predictive
    Risk
    Opis:
    Despite recording the worst heavy metal disaster involving children, there is still scarcity of information on risk assessment of playground soils in Nigeria. In this study, thirty-six soil samples at 0-5 cm depth were collected from nine playgrounds in Owerri metropolis during the dry and rainy seasons. Five heavy metals were fractionated into six chemical fractions using a modified sequential extraction scheme and mean concentrations quantified by AAnalyst 400 Perkin Elmer AAS. Predictive risk models were used to obtain information about the risk of metals contamination to children using these playgrounds for longer periods. These reveal that there were no significant differences in the mean values of bioconcentration factors of all five metals in the various playgrounds for the two years of data. Even though risk values for both dry and rainy season followed the same trend, it was observed that the Zinc showed highest bioconcentration factors (1.6), average daily dose (230.08 mg/kg/day) and risk (5095593 mg/kg/6years). Over all, playgrounds UPS, TSO and SCP had highest mean risk values, respectively. Though with no clear trend, mobility factors showed a weak and positive correlation with risk. Children in playgrounds of public schools within Owerri metropolis could, therefore, be at risk of Mn, Cu and Zn toxicity problems as projected risk values were high for all studied playgrounds. This assessment could help identify playgrounds with urgent need for heavy metals reduction goals, consequently contributing to preserving children’s health.
    Źródło:
    World News of Natural Sciences; 2017, 10; 49-69
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mass Violence Detection Using Data Mining Techniques
    Autorzy:
    Varma, Rishabh
    Ahmad, Sartaj
    Powiązania:
    https://bibliotekanauki.pl/articles/1159845.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Data mining
    Predictive model
    Text mining
    Tweet analysis
    Opis:
    The world is now witnessing a tectonic shift in the way in which people react to social and economic impacts such as rise in fossil fuel prices, implication of new rules and regulations, and other situations which directly affect the emotions of a certain group of people. Violence is the most widely used way of expressing anger and discontent for a particular situation which might have occurred. Such actions can cause loss of millions of dollars and precious lives of people who come in way of such protests. These protests are mainly conducted through social media platforms such as twitter as it is not possible to personally communicate to tens of thousand people to accumulate at a certain place, therefore it is extremely important as well as necessary to keep an eye on the social media statuses and updates of people in the times of crisis and heavy tension. This paper aims to collect the tweets of people uploaded on twitter and then process them to find out the location, time and intensity of the mass violence so that the responsible authorities can handle the situation and prevent violence.
    Źródło:
    World Scientific News; 2018, 113; 218-225
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Some aspects of the speech process
    Autorzy:
    Suleymanova, N. M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1182526.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    derivation
    external speech
    internal speech
    nominative aspect
    predictive aspect
    speech process
    Opis:
    This article investigates with linguistic aspects of speech process and its nominative aspects, including all units of language and speech while taking into consideration of intersections. As there number of unlike viewpoints the syntax of external speech is diverse from internal speech syntax, because the internal speech is for the speaker and external speech pointed at someone. Final outcomes and shortcoming of the research may lead to better investigation as whole.
    Źródło:
    World Scientific News; 2017, 69; 190-200
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    QSAR modeling for prediction of acute toxicity and mutagenicity in different test models by established common phytochemicals present in Phyllanthus niruri
    Autorzy:
    Dhar, Shrinjana
    Gupta, Kaushik
    Talapatra, Soumendra Nath
    Powiązania:
    https://bibliotekanauki.pl/articles/1192089.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    QSAR modeling
    Common phytochemicals
    Phyllanthus niruri
    T.E.S.T. software
    Predictive toxicity and mutagenicity
    Opis:
    In globe, Pyllanthus niruri is a well-established medicinal herb studied by many researchers, grown widely in many parts of West Bengal. The present study was aimed to predict the acute toxicity as LC50 in Daphnia magna and Pimephales promelas and rat oral LD50 value as well as Ames mutagenicity by using QSAR modeling software, T.E.S.T. (Toxicity Estimation Software Tool) for commonly found phytochemicals in Pyllanthus niruri. In present works, the data were obtained for LC50, few phytochemicals were toxic to D. magna and P. promelas and also mutagenic but rat oral LD50 determined less toxic. The present QSAR modeling work is suggesting that more researches should be required through experimental as well as predictive study with other prescribed software to know the mechanisms of toxicity and mutagenicity for these combined form of phytochemicals after separating each natural chemical from extract prior to drugs development for therapeutic usage.
    Źródło:
    World Scientific News; 2016, 37; 202-219
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Predictive acute toxicity comparison in Daphnia magna for common organic chemicals present in cosmetics by using two QSAR modeling softwares
    Autorzy:
    Talapatra, Soumendra Nath
    Konar, Sarnali
    Powiązania:
    https://bibliotekanauki.pl/articles/1190143.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    QSAR modelling
    Cosmetic organic chemicals
    T.E.S.T. and ECOSAR software
    Predictive acute toxicity
    Daphnia magna
    Opis:
    Different types of organic compounds, which are used in cosmetics from decades. The usage of cosmetic products are mainly by people in office, culture, festival, recreation etc. All of these chemicals are of synthetic origin. The present study aims to predict comparative acute toxicity as LC50 (median lethal concentration) values in Daphnia magna for common types of cosmetic compounds. The predictions of LC50 values were determined by using two QSAR modeling softwares, T.E.S.T. or Toxicity Estimation Software Tool and ECOSAR (Ecological Structure Activity Relationship), for established 23 types of chemicals commonly present in cosmetics. These two softwares help to predict of LC50 values by easy screening. In present result, predictive data with statistical interpretation (R2 or correlation coefficient values) were obtained easily in T.E.S.T. but not in ECOSAR and the statistical data interpretation was not found. Among all these chemicals, it was observed that major compounds are not toxic to D. magna except few chemicals viz. ascorbyl palmitate, triclosan, methyl triclosan and triclocarbon. Further researches are suggested to compare these predicted data with other available 2-dimentional and 3-dimentional softwares and these chemicals should be studied in combinations of cosmetic chemicals with this test model in vivo because they are major food sources for fish in freshwater ecosystem.
    Źródło:
    World Scientific News; 2016, 42; 101-118
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In silico study by using ProTox-II webserver for oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling and stress response pathways of synthetic pyrethroids
    Autorzy:
    Ghosh, Subhasis
    Tripathi, Puja
    Talukdar, Partha
    Talapatra, Soumendra Nath
    Powiązania:
    https://bibliotekanauki.pl/articles/1065392.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    In silico study
    Molecular mechanism of toxicity
    Nuclear receptor signalling and stress response pathways
    Predictive toxicology
    Synthetic pyrethroids
    Opis:
    Till date, it is well-known that synthetic pyrethroids are safe to mammal but toxic to non-mammals. The present objective was an in silico study to detect oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling, and stress response pathways of common synthetic pyrethroids by using ProTox-II webserver. The chemical compounds especially different synthetic pyrethroids such as pyrethrin I, Cinerin I and Jasmolin I (esters of Chrysanthemic acid), Pyrethrin-II, Cinerin II and Jasmolin II (Esters of Pyrethric acid), type I pyrethroids (esters without alpha-cyano group) such as allethrin, resmethrin, permethrin and bifenthrin and type II pyrethroids (esters with alpha-cyano group) such as fenvalerate, cyhalothrin, cypermethrin and deltamethrinwere selected from available literature. ProTox-II webserver was used for toxicological assessment in organism, organs, cell and gene level along with molecular mechanisms of toxicity. The predictive results for the toxicity of common synthetic pyrethroids compounds, Deltamethrin showed highly toxic compound among 14 compounds as fatal if swallowed as class II followed by Cypermethrin, Cyhalothrin, Bifenthrin, Resmethrin, Fenvalerate and Permethrin but hepatotoxic potential was only Deltamethrin and Fenvalerate while immunotoxic was obtained Permethrin. On the other hand, none of the compounds were obtained cytotoxic and carcinogenic but 9 compounds viz. Pyrethrin I, II Cinerin I, II, Jasmolin I, II, Allethrin, Resmethrin and Permethrin were observed mutagenic active. In case of NR signalling pathways, all compounds were inactive but eight compounds such as Pyrethrin I, II, Cinerin I, II, Jasmolin I, II, Allethrin and Resmethrin were obtained nrf2/ARE and HSE active while MMP active compounds were obtained Fenvalerate, Cyhalothrin and Deltamethrin respectively. For p53 and ATAD5 parameters, all fourteen compounds such as were obtained inactive. In conclusion, the present predictive results are suitable for academician, researchers, industries, etc. those who are making drugs and environmental chemicals. This web server helps faster screening of large numbers of compounds within short duration and no animal testing. This present in silico study easily detects toxin(s), which can be validated in future through in vitro and in vivo experimental assay.
    Źródło:
    World Scientific News; 2019, 132; 35-51
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Computational predictive mutagenicity of similar chemicals for anthraquinone, β-sitosterol and quercetin found in Alternanthera tenella by using QSAR modeling software
    Autorzy:
    Haque, Mahmudul
    Bhakat, Ram Kumar
    Bhattacharjee, Aloke
    Talapatra, Soumendra Nath
    Powiązania:
    https://bibliotekanauki.pl/articles/1182926.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Allelopathy; Allelochemicals; Alternanthera tenella; Invasive species; Terrestrial ecosystem; Predictive Ames mutagenicity; QSAR modeling; T.E.S.T. software
    Opis:
    The present study aims to evaluate the mutagenic potential of secondary metabolites viz. anthraquinone, β-sitosterol and quercetin present in Alternanthera tenella and their related analogus compounds similar in their molecular structure. Nine similar putative allelochemicals analogus to each of anthraquninone, β-sitosterol and quercetin respectively were selected, a total of twenty seven similar chemicals were studied for mutagenicity prediction. Ames mutagenicity prediction was carried out by using T.E.S.T. (Toxicity Estimation Software Tool) of USEPA. All experimental metadata were obtained from Toxicity Benchmark and T.E.S.T. The results clearly indicated that the allelochemicals, anthraquinone and its related eight compounds were mutagenic positive except benzanthrone (mutagenic negative) but all experimental data were found mutagenic positive. β-sitosterol showed mutagenic negative in both experimental and predicted value. It’s three related compounds were mutagenic positive but rest six related compounds mutagenic negative in predicted value while in experimental data, seven compounds were found mutagenic positive and rest two mutagenic negative. In case of quercetin, both data were obtained mutagenic positive while in related compounds, seven compounds were found to be mutagenic positive and two compounds mutagenic negative in predicted value. All were found to be mutagenic positive in experimental metadata. Such findings poses a curiosity that are there any possibilities of conversion or substitution in the position of aromatic ring of allelochemicals when present in soil? Because allelopathy depends upon several environmental stressors and mutagenicity may be induced by allelochemicals. It is suggesting for future research to detect metabolic pathway and mechanism of allelochemicals formation in A. tenella in presence of toxins in soil and to validate with other available 2D and 3D softwares.
    Źródło:
    World Scientific News; 2016, 49, 2; 162-191
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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