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Wyświetlanie 1-7 z 7
Tytuł:
Determination of kinetic parameters of decomposition of tetrahydropyrimidine derivatives
Autorzy:
Bhesaniya, K.
Patel, A.
Baluja, S.
Powiązania:
https://bibliotekanauki.pl/articles/411745.pdf
Data publikacji:
2013
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
tetrahydropyrimidine derivative
TGA
DSC
kinetic parameter
Opis:
Some new tetrahydropyrimidine derivatives have been synthesized and their structural determination was done by IR, NMR and mass spectral data. Thermal analysis of these synthesized dihydropyrimidinthiones has been carried out by TGA and DSC techniques. From the thermograms, various kinetic parameters such as order of degradation (n), energy of activation (E), frequency factor (A) and entropy change (ΔS) have been evaluated. Further, thermal stability of tetrahydropyrimidine have been determined which is found to depend on the type of substituent present in the compounds.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2013, 13; 23-32
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sustain release Formulation and Evaluation of Ofloxacin floating delivery system
Autorzy:
Patel, A. J.
Naik, D. R.
Raval, J. R.
Powiązania:
https://bibliotekanauki.pl/articles/412207.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
ofloxacin
ethyl cellulose
xanthum gum
floating drug delivery System
controlled release
Opis:
Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 12; 69-83
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mesogenic Dependence of Chalconyl Schiff’s Bases on Molecular Rigidity and Flexibility
Autorzy:
Pandya, S. H.
Patel, V. R.
Doshi, A. V.
Powiązania:
https://bibliotekanauki.pl/articles/1178290.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Enantiotropy
Liquid Crystals
Mesomorphism
Nematic
Smetic
Opis:
A novel homologous series R0-C6H4.CH:N-C6H4.CO.CH:CH-C6H4-OC6H13(n) of liquid crystal property is synthesized and studied with a view to understand and establish the effect of molecular structure on liquid crystal properties with respect to Schiff base and chalconyl central bridges as well as changing left n-alkoxy terminal and right n-hexyloxy fixed tail ended group. Homologous series consisted of eleven (C1 to C16) homologues in which the nematogenic mesomorphism commences from C3 homologue and continued to last C16 homologue without exhibition of smectogenic property. Rest of the C1 and C2 homologues are nonmesomorphic, whose Latent transition temperature (LTT) are predicted by extrapolation of N-I transition curves. Odd-even effect is observed for N-I transition curve. N-I transition curve and Cr-N/I transition curve behaved in normal manner. The Nematic thermal stability is 72.2 ° C. The minimum and maximum nematogenic mesophaselengths are ranging between 12.0 °C and 30.0 °C at C16 and C14 homologue respectively. Transition temperatures were determined by an optical polarizing microscopy (POM), equipped with a heating stage. Thermal analytical and spectral data confirms the molecular structures of homologues. The novel homologous series of chalconyl Schiff’s base is low melting series, whose mesogenic transition temperatures ranges between 43.0 °C and 79.0 °C.
Źródło:
World Scientific News; 2017, 86, 3; 242-252
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nematogenic Mesophase Induced from Two Nonmesomorphs and Determination of LTT for Common Nonmesomorphic Component by Extrapolation
Autorzy:
Solanki, Ravindra
Patel, R. B.
Doshi, A. V.
Powiązania:
https://bibliotekanauki.pl/articles/1179586.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Binary System
Eutectic point
Mixed melt
Mixed mesomorphism
Nematic
Opis:
Three binary systems (A+B1, A+B2, A+B3) consisted of both admixed components as nonmesomorphs induces mesomorphic property as nematogenic mesophase within definite range of concentration of component - A. The Isotropic- Nematic (I-N) transition curves of each binary systems are extra polated to 100 mole percent of nonmesomorphic component –A to determine its reliable latent transition temperature (LTT) and to derive the group efficiency order. The common component A is a Schiff’s base, P-tolal. P’- Phenetidine (109 °C), uncommon component B1 and B2 are also Schiff’s bases p-Chloro benzal P’- chloroaniline (M.P 111.0 °C) and p-Anisal p’-Toluidine (M.P 92.0 °C) respectively, whereas, component B3 is a chalcone α- 4 methoxy phenyl β 4’-pentyloxy benzoyl ethylene (M.P 91.0 °C). The reliable predicted LTT of common component –A are 99.5 °C, 99.0 °C and 101.0 °C from binary systems A+B1 ,A+B2 and, A+B3 respectively. The group efficiency order derived is B2>B1>B3 from range of mesomorphism.The melting point of common and uncommon nonmesomorphic components are confirmed with previously reported values. Suitable magnitudes of anisotropic forces of intermolecular attractions as a consequence of resulted molecular rigidity and flexibility through respective polarity and polarizabilities of nonmesogenic components of the mesogenic mixitures which play an important role in inducing mesomorphism.
Źródło:
World Scientific News; 2017, 74; 68-79
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Environmentally and Economically Feasibility Manufacturing Process of Potassium Nitrate for Small Scale Industries: A Review
Autorzy:
Joshi, C. S.
Shukla, M. R.
Patel, K.
Joshi, J. S.
Sahu, O.
Powiązania:
https://bibliotekanauki.pl/articles/411997.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chemical
discharge
ions
Salts
Waste
Opis:
Potassium Nitrate (PN) is of the basic need of chemical industry. With increase of demand in different production section of fertilizer, pharmaceutical, explosive, food industry etc, potassium nitrate the production becoming non economical to industry. The operating conditions and parameters are the main factors, which responsible for maximised the profits. The main aim of this study is to compared the production potassium nitrate in profitable as well as environmentally suitability way. From the literature different manufacturing process has been summarized for concluding this study.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2015, 41; 88-99
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A convergent approach for the synthesis of new pyrazolyl bipyridinyl substituted coumarin derivatives as antimicrobials
Autorzy:
Bhila, V. G.
Chovatiya, Y. L.
Patel, C. V.
Giri, R. R.
Brahmbhatt, D. I.
Powiązania:
https://bibliotekanauki.pl/articles/411982.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Coumarin
Bipyridine
Pyrazole
Kröhnke’s reaction
antimicrobial activity
Opis:
Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)acryloyl]coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competency of the title compounds was assessed against selected pathogens. Compounds 3b, 3e, 7b, 8b, 8c and 9b exhibited excellent antimicrobial activity and said to be the most proficient members of the series.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2015, 40; 1-16
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and Characterization of N-Methyl Indole Derivatives via Desulfitative Displacement by Various Amines and Its Antimicrobial Activity
Autorzy:
Chodvadiya, Vijay D.
Pambhar, Kaushik D.
Parmar, Nilesh D.
Dhamsaniya, Ashish P.
Safi, Shahrukh khan A.
Chhatbar, Pratiksha V.
Ram, Hemal N.
Khunt, Ranjan C.
Patel, P. K.
Powiązania:
https://bibliotekanauki.pl/articles/1065130.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Anti-microbial agents
Desulfitative displacement
N-methyl indole
S-methyl
Opis:
A modular three step synthetic approach of N-methyl indole derivatives has been carried out by the condensation of N-methyl indole with cyanoacetic acid using acetic anhydride as solvent to yield 3-cyanoacetyl N-methyl indole, which further reacts with carbon disulphide and methyl iodide in basic condition to obtain 2-(1-methyl-1H-indole-3-carbonyl)-3,3-bis(methylthio)acrylonitrile as a scaffold. Subsequent, the scaffold when reacts with substituted various amine derivatives via desulfitative displacement forms new derivatives of 3-((substitutedphenyl)amino)-2-(1-methyl-1H-indole-3-carbonyl)-3-(methylthio)acrylonitrile in moderate to good yields. All the novel compounds were evaluated for their antimicrobial activity against Gram+ve and Gram-ve bacteria and different fungal species which demonstrated well to moderate antimicrobial activity.
Źródło:
World Scientific News; 2019, 120, 2; 181-191
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-7 z 7

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