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Wyświetlanie 1-15 z 26
Tytuł:
Molekularne mechanizmy lekoopornosci pasozytow
Autorzy:
Majewska, A C
Powiązania:
https://bibliotekanauki.pl/articles/839311.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
lekoopornosc
parazytologia
mechanizmy molekularne
pasozyty
Opis:
In spite of the enormous achievements of medical and biological sciences, parasites still constitute important medical and veterinary problem. One of the main obstacles in the treatment and eradication of human and animals parasitic diseases is drug resistance of parasites. This phenomenon has more and more frequently been described both in medical and veterinary practice. The application of numerous molecular biology techniques in modern parasitological laboratories have enabled the investigations of parasites at the DNA level. The results of these studies have revolutionised our knowledge and made possible the recognition of not only the reasons and extent of genetic differentiation of parasites but also the recognition of genetic and molecular mechamisms of drug resistance. The results of many studies showed interspecific, interpopulational, and even intrapopulational heterogeneity of parasites in their sensitivity to antiparasitic drugs. Moreover, it has been found that in various parasites there often exist different molecular bases of the drug resistance. The review concerns different molecular mechanisms of drug resistance in selected parasite taxa (Schistosoma spp., Haemonchus contortus, Leishmania spp., Plasmodium falciparum, Entamoeba histolytica).
Źródło:
Annals of Parasitology; 1998, 44, 2; 139-150
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molekularne mechanizmy lekooporności pasożytów
Autorzy:
Majewska, A. C.
Powiązania:
https://bibliotekanauki.pl/articles/2148863.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
lekoopornosc
parazytologia
mechanizmy molekularne
pasozyty
Opis:
In spite of the enormous achievements of medical and biological sciences, parasites still constitute important medical and veterinary problem. One of the main obstacles in the treatment and eradication of human and animals parasitic diseases is drug resistance of parasites. This phenomenon has more and more frequently been described both in medical and veterinary practice. The application of numerous molecular biology techniques in modern parasitological laboratories have enabled the investigations of parasites at the DNA level. The results of these studies have revolutionised our knowledge and made possible the recognition of not only the reasons and extent of genetic differentiation of parasites but also the recognition of genetic and molecular mechamisms of drug resistance. The results of many studies showed interspecific, interpopulational, and even intrapopulational heterogeneity of parasites in their sensitivity to antiparasitic drugs. Moreover, it has been found that in various parasites there often exist different molecular bases of the drug resistance. The review concerns different molecular mechanisms of drug resistance in selected parasite taxa (Schistosoma spp., Haemonchus contortus, Leishmania spp., Plasmodium falciparum, Entamoeba histolytica).
Źródło:
Wiadomości Parazytologiczne; 1998, 44, 2; 139-150
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opornosc stawonogow hematofagicznych - narastajacy problem. 1.Mechanizmy opornosci na insektycydy
Autorzy:
Kedra, E
Powiązania:
https://bibliotekanauki.pl/articles/838355.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy opornosciowe
opornosc na insektycydy
stawonogi
hematofagi
Opis:
Resistance in the hematophagous arthropods - problem on the rise. I. Resistance mechanisms to insecticides. Hematophagous arthropods are pesky but can also be very dangerous to human health due to their ability to act as vectors to many viral, bacterial or parasite-related diseases. The common application of chemicals to control pests leaded to the increasing resistance to pesticides among both insects and ticks. The causes underlying the appearance of the resistance and the mechanisms involved are presented in this article. The description of mechanisms is presented starting from decreased penetration of the pesticide, to an increase in metabolism of pesticide, to the reduced sensitivity of the pesticide's target.
Źródło:
Annals of Parasitology; 2003, 49, 4; 351-356
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oporność stawonogów hematofagicznych - narastający problem. 1.Mechanizmy oporności na insektycydy
Autorzy:
Kędra, E.
Powiązania:
https://bibliotekanauki.pl/articles/2147664.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy opornosciowe
opornosc na insektycydy
stawonogi
hematofagi
Opis:
Resistance in the hematophagous arthropods - problem on the rise. I. Resistance mechanisms to insecticides. Hematophagous arthropods are pesky but can also be very dangerous to human health due to their ability to act as vectors to many viral, bacterial or parasite-related diseases. The common application of chemicals to control pests leaded to the increasing resistance to pesticides among both insects and ticks. The causes underlying the appearance of the resistance and the mechanisms involved are presented in this article. The description of mechanisms is presented starting from decreased penetration of the pesticide, to an increase in metabolism of pesticide, to the reduced sensitivity of the pesticide's target.
Źródło:
Wiadomości Parazytologiczne; 2003, 49, 4; 351-356
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apoptoza jako mechanizm ochronny dla patogenow i ich zywicieli
Autorzy:
Donskow-Schmelter, K.
Doligalska, M.
Powiązania:
https://bibliotekanauki.pl/articles/839428.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
patogeny
apoptoza
pasozyty
mechanizmy ochronne
interakcje pasozyt-zywiciel
zywiciele
Źródło:
Annals of Parasitology; 2005, 51, 4; 271-280
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apoptoza jako mechanizm ochronny dla patogenów i ich żywicieli
Apoptosis, A Protective Mechanism for Pathogens and Their Hosts
Autorzy:
Donskow-Schmelter, K.
Doligalska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2146403.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
patogeny
apoptoza
pasozyty
mechanizmy ochronne
interakcje pasozyt-zywiciel
zywiciele
Opis:
In this review we summarize the great amount of recent information on the apoptosis in aspeets of the host-parasite interaction. Although apoptosis is a form of programmed cell death which plays a pivotal role in normal tissue development a plethora of pathogens including parasitic protista and helminths are able to modulate host apoptosis pathways to their own advantage. Here in we present and discuss new research data and results describing the phenomenon as a process have been controlled by gene expression, biochemical reactions and receptor-ligand interactions at the cell membrane surface. Section | describes apoptosis as ongoing process in normal tissue development. Section 2 analyzes the role of apoptosis in outcome of infection and pathogenesis of several disorders evoked by viruses and bacteria. The cellular mechanisms of cell death during infection with unicellular parasites such as Leishmania sp. and Plasmodium sp. are described in Section 3. In the next paragraph the potency of parasitic protista and helmiths for modulation host apoptosis pathways to their own advantage is discussed. The involvement of apoptosis in immunoregulation of the host immune function was proposed as a one of possible mechanism in creation of the host-parasite relationship. The molecular and cellular mechanisms of parasite-induced immune response via apoptosis pathways are discussed. We conclude that novel strategies for the management of the host-parasite relationships need to be explained into the mechanisms by which parasites induced apoptosis in contribution to the activity of immune system of the host.
Źródło:
Wiadomości Parazytologiczne; 2005, 51, 4; 271-280
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wolnorodnikowe mechanizmy biochemicznej obrony zywiciela
Autorzy:
Boczon, K
Hadas, E.
Powiązania:
https://bibliotekanauki.pl/articles/838939.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy obronne
interakcje zywiciel-pasozyt
biochemia
parazytologia
wolne rodniki
zywiciele
Opis:
The mechanism of intracellular killing of pathogens which involves both oxygen and reactive nitrogen intermediates have been discussed. The attention is focused on inducible nitric oxide synthase which produces NO, a soluble free radical. The role of nitric synthase in the pathogenesis of many parasitic infections has recently been emphasised. The participation of enzymatic and non-enzymatic antioxidants in the pathogenesis of many infections and the role of proteasomes in the process of repair of the oxidetively damaged proteins are also discussed.
Źródło:
Annals of Parasitology; 1998, 44, 2; 169-174
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wolnorodnikowe mechanizmy biochemicznej obrony żywiciela
THE ROLE OF FREE RADICALS IN THE BIOCHEMICAL DEFENCE MECHANISM OF THE HOST
Autorzy:
Boczoń, K.
Hadaś, E.
Powiązania:
https://bibliotekanauki.pl/articles/2148866.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy obronne
interakcje zywiciel-pasozyt
biochemia
parazytologia
wolne rodniki
zywiciele
Opis:
The mechanism of intracellular killing of pathogens which involves both oxygen and reactive nitrogen intermediates have been discussed. The attention is focused on inducible nitric oxide synthase which produces NO, a soluble free radical. The role of nitric synthase in the pathogenesis of many parasitic infections has recently been emphasised. The participation of enzymatic and non-enzymatic antioxidants in the pathogenesis of many infections and the role of proteasomes in the process of repair of the oxidetively damaged proteins are also discussed.
Źródło:
Wiadomości Parazytologiczne; 1998, 44, 2; 169-174
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Odpowiedz immunologiczna na zarazenie grzybami
The immune response to fungal infections
Autorzy:
Kurnatowski, P
Kurnatowska, A.J.
Powiązania:
https://bibliotekanauki.pl/articles/838620.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
patogeny grzybowe
infekcja grzybowa
grzybice
mechanizmy odpornosciowe
uklad odpornosciowy
odpowiedz immunologiczna
Źródło:
Annals of Parasitology; 2010, 56, 1; 23-27
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunologiczne mechanizmy oddzialywan zywiciel - pasozyt w ukladzie slimak - przywra
Autorzy:
Kofta, W
Powiązania:
https://bibliotekanauki.pl/articles/840249.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
interakcje zywiciel-pasozyt
mechanizmy odpornosciowe
przywry
slimaki
parazytologia
immunologia
pasozyty
zywiciele
Opis:
This is a review article based on about 100 papers from leading world newspapers. The main features and the way of action of the snail's immune system are described. The mechanisms of discrimination between self and non-self are presented in detail, including characterization of interacting components of host (cellular and humoral factors) and parasite (a sporocyst surface) origin. The phenomena of molecular disguise and molecular mimicry are discussed in the context of the compatibility betweeen a host and a parasite. The possible ways of killing parasite are indicated, with special regard to production of reactive oxygen intermediates by hemocytes during the process of killing.
Źródło:
Annals of Parasitology; 1994, 40, 3; 229-251
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Odpowiedź immunologiczna na zarażenie grzybami
The immune response to fungal infections
Autorzy:
Kurnatowski, P.
Kurnatowska, A.J.
Powiązania:
https://bibliotekanauki.pl/articles/2143402.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
patogeny grzybowe
infekcja grzybowa
grzybice
mechanizmy odpornosciowe
uklad odpornosciowy
odpowiedz immunologiczna
Opis:
In mycoses congenital – nonspecific innate as well as acquired immunity (involving neutrophiles, monocytes, macrophages, dendritic cells and lymphocytes) both play important roles in host defence. Th1 lymphocytes release cytokines (IL-2, IL-12, IFNg) and stimulate cytotoxic cells and neutrophiles to destroy fungal cells. Th2 lymphocytes, on the other hand, suppress cellular immunity by releasing the cytokines IL-4, IL-6 and IL-10 which counter regulate the secretion of IL-2, IL-12, IFNg and depress the activity of macrophages. Cellular mechanisms play essential roles in host responses to fungal infections. Dysfunction of T lymphocytes and a reduction in their number are typically observed in patients with mycotic diseases. There occurs a reduction of both T lymphocyte populations and the T-helper to T-suppressor cell number ratio, and these are of critical importance in explaining the diminished IgA production and enhanced adhesion of fungal cells to the surface of host cells as well as in facilitating the intrusion of fungi throughout the skin and mucous membranes. The specific immunological reaction, associated with the synthesis of antibodies against fungal cell wall or cytoplasmic antigens, is of little significance in protective immunity, but nevertheless has a rather important role to play in diagnosis as well as in supporting phagocytosis by inhibition of fungal cell adherence. In patients with mycoses, typically low blood serum level of the immunoglobulin class G and A and low sIgA in saliva are observed. A detailed understanding the nature and function of the immune system in mycoses is necessary to enable improvements in pharmacotherapy with antifungal antibiotics and chemotherapeutics, as well as to treatments based on immunotherapy and vaccination.
Źródło:
Wiadomości Parazytologiczne; 2010, 56, 1; 23-27
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunologiczne mechanizmy oddziaływań żywiciel - pasożyt w układzie ślimak - przywra
Autorzy:
Kofta, W.
Powiązania:
https://bibliotekanauki.pl/articles/2151458.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
interakcje zywiciel-pasozyt
mechanizmy odpornosciowe
przywry
slimaki
parazytologia
immunologia
pasozyty
zywiciele
Opis:
This is a review article based on about 100 papers from leading world newspapers. The main features and the way of action of the snail's immune system are described. The mechanisms of discrimination between self and non-self are presented in detail, including characterization of interacting components of host (cellular and humoral factors) and parasite (a sporocyst surface) origin. The phenomena of molecular disguise and molecular mimicry are discussed in the context of the compatibility betweeen a host and a parasite. The possible ways of killing parasite are indicated, with special regard to production of reactive oxygen intermediates by hemocytes during the process of killing.
Źródło:
Wiadomości Parazytologiczne; 1994, 40, 3; 229-251
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wolne rodniki w inwazji pasozytniczej
Autorzy:
Balinska, M
Powiązania:
https://bibliotekanauki.pl/articles/839864.pdf
Data publikacji:
1992
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy odpornosciowe
odpowiedz immunologiczna
pasozyty zwierzat
parazytologia
immunologia
inwazja pasozytnicza
wolne rodniki
Opis:
Highly reactive oxygen species potentially represent a powerful effector mechanism against parasites. They are produced during normal cellular metabolism, especially by activated phagocytes. As can be seen from many studies protozoan and helminth parasites appear to have one or more anti-oxidant enzymes able to scavenge or quench the reactive free-radicals, and there is strong evidence that such enzymes may play crucial role in protecting against host response. Presented there review illustrates that methods to block anti-oxidant protection of parasites may be new field in the search for improved ways to inhibit parasitic survival.
Źródło:
Annals of Parasitology; 1992, 38, 1-2; 17-22
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wolne rodniki w inwazji pasożytniczej
FREE-RADICALS IN PARASITIC INVASION
Autorzy:
Balińska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2152238.pdf
Data publikacji:
1992
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy odpornosciowe
odpowiedz immunologiczna
pasozyty zwierzat
parazytologia
immunologia
inwazja pasozytnicza
wolne rodniki
Opis:
Highly reactive oxygen species potentially represent a powerful effector mechanism against parasites. They are produced during normal cellular metabolism, especially by activated phagocytes. As can be seen from many studies protozoan and helminth parasites appear to have one or more anti-oxidant enzymes able to scavenge or quench the reactive free-radicals, and there is strong evidence that such enzymes may play crucial role in protecting against host response. Presented there review illustrates that methods to block anti-oxidant protection of parasites may be new field in the search for improved ways to inhibit parasitic survival.
Źródło:
Wiadomości Parazytologiczne; 1992, 38, 1-2; 17-22
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola tlenku azotu w inwazjach pasożytniczych
The role of nitric oxide (NO) in parasitic infections
Autorzy:
Wandurska-Nowak, E.
Powiązania:
https://bibliotekanauki.pl/articles/2147575.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mechanizmy obronne
toksoplazmoza
tlenki azotu
odpowiedz immunologiczna
schistosomoza
choroby pasozytnicze
parazytologia
inwazja pasozytnicza
trypanosomoza
leiszmanioza
malaria
Opis:
Nitric oxide (NO) has been shown to play a crucial role in various physiological and pathological conditions. NO plays a role in the immunoregulation and it is implicated in the host non-specific defence in a variety of infections. Abundant evidence indicates that NO contributes to the host defence function of macrophages. High levels of NO are mediated by up-regulated expression of the iNOS gene in response to the activating signals, in particular to the secretion of pro-inflammatory cytokines (IFN-y, TNF-a, IL-1, IL-2) by Thl cells. In this review, the role of NO during a number of parasitic infections has been summarized. Up to now, enhanced levels of NO production and expression of iNOS gene have been described in such infective diseases as malaria, toxoplasmosis, leishmaniosis, trypanosomosis and schistosomosis. During these infections, the preferential production of pro-inflammatory cytokines predisposes to the increased synthesis of NO, which mediates host protection through either direct parasite killing or by limiting parasite growth. The evidence presented in this review supports the conclusion that NO plays an important role in the majority of parasitic infections.
Źródło:
Wiadomości Parazytologiczne; 2004, 50, 4; 665-678
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 26

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