Temat: trastuzumab - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Trastuzumab Efficacy Quantified by Fluorine-19 Magnetic Resonance Imaging
Autorzy:: Bartusik-Aebisher, Dorota
Aebisher, David
Czmil, Mrs Anna
Mazur, Damian
Powiązania:: https://bibliotekanauki.pl/articles/895489.pdf
Data publikacji:: 2020-06-29
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: trastuzumab
magnetic resonance imaging
breast cancer cells
three-dimensional cell culture
Trastuzumab conjugates
Opis:: The purpose of this study was to conjugate Trastuzumab with fluorine-bearing PAMAM dendrimer to compare activities in three-dimensional (3D) cultured breast cancer cells with parent Trastuzumab. An in vitro study was performed to determine cellular responses to fluorinated Trastuzumab conjugates by Magnetic Resonance Imaging (MRI). Breast cancer cells were cultured in 3D geometry. Proton (1H) MRI and Fluorine-19 (19F) MRI were used for visualization of cellular locations within a Hollow Fiber Bioreactor (HFBR) device and to monitor the cellular response to treatment. The results of this study confirm that cell growth is significantly decreased following treatment with Trastuzumab conjugates. The use of fluorinated Trastuzumab conjugates decreases breast cancer cell growth in 3D cultures and allows for tracking of drug delivery to cancer cells via 19F.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 495-503
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Trastuzumab-dendrimer-fluorine drug delivery system
Autorzy:: Bartusik-Aebisher, Dorota
Powiązania:: https://bibliotekanauki.pl/articles/895535.pdf
Data publikacji:: 2020-04-29
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: trastuzumab
Dendrimer
Drug delivery system
Her-2 receptor
Opis:: Breast cancer is the most frequently occurring cancer in women worldwide with more than one million new cases diagnosed each year. The objective of this study was to develop a Trastuzumab-dendrimer-fluorine drug delivery system by covalent attachment of Trastuzumab to a fluorinated PAMAM-G5 dendrimer. The Trastuzumab-dendrimer-fluorine drug delivery system was used to treat MCF-7 with Her-2 overexpression. The use of PAMAM-G5, which bears 128 primary amine surface groups, enables covalent attachment of both antibody and fluorinated functional groups for enhancement of cellular uptake. Thus, Trastuzumab was covalently attached to fluorinated PAMAM-G5 dendrimers and used as a vehicle for drug delivery to three dimensional (3D) cultured cells. The efficiency of Trastuzumab-dendrimer-fluorine drug delivery system binding to Her-2 receptors was measured by cell viability. The Trastuzumab-dendrimer-fluorine drug delivery system was found to have a higher efficiency in the treatment of Her-2 overexpressing MCF-7 cells than Trastuzumab alone. The incorporation of 19F by addition of heptafluorobutyric acid anhydride (HFAA) to PAMAM-G5 increased lipophilicity and hydrophobicity of drug delivery system.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 331-341
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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