- Tytuł:
- Synthesis and study of substituted amides of some 5-membered isocyclic and heterocyclic acids as potential anticonvulsants
- Autorzy:
-
STRUPIŃSKA, MARZANNA
JAKUBOWICZ, BARTŁOMIEJ
ROSTAFIŃSKA-SUCHAR, GRAŻYNA
PIRIANOWICZ-CHABER, ELŻBIETA
KONAROWSKA, MAGDALENA
MAZUREK, ALEKSANDER P. - Powiązania:
- https://bibliotekanauki.pl/articles/895607.pdf
- Data publikacji:
- 2018-06-30
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
Maximal electroshock seizure test
anticonvulsant activity
substituted benzylamides of isocyclic acids
substituted benzylamides of heterocyclic acids
psychomotor seizure test - Opis:
- A series of substituted amides of isocyclic and heterocyclic acids have been synthesized. All obtained compounds were evaluated qualitatively for their anticonvulsant activity in the maximal electroshock seizure test (MES test) and psychomotor seizure test (6 Hz test) in mice after intraperitoneal administration. The neurological toxicity was determined in the rotorod neurotoxicity test (Tox test). Two of these compounds appeared most promising: 3-oxo-1-cyklopentanecarboxylic acid 2-fluorobenzylamide (5), 1-cyclopentenecarboxylic acid 2-(trifluoromethyl)benzylamide (8) and were tested quantitatively in MES test in mice after oral administration (o.p.) and in 6 Hz test in mice after intraperitoneal administration(i.p.). Compound (5) showed MES ED50 =82.65 mg/kg and compound (8) showed 6 Hz ED50=84.13 mg/kg.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł