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Wyszukujesz frazę "magnetic imaging" wg kryterium: Temat

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    Wyświetlanie 1-4 z 4
    Tytuł:
    MRI as a potential tool for monitoring of therapeutic monoclonal antibody distribution in cancer patients
    Autorzy:
    Tabarkiewicz, Jacek
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/895617.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    monoclonal antibody
    magnetic resonance imaging
    fluorine
    cancer diagnostics
    Opis:
    Imaging and quantification of MAbs distribution by MRI after administration in vivo can improve patient outcomes, although it is not routinely used in the clinic hence the motivation for development of new MAbs imaging methodologies. Improvements in imaging and quantification of antibody distributions can be made by conjugating MAbs to “hotspot” atoms such as 19F as 19F Currently, research investigating the incorporation of 19F to antibody delivery systems has been limited to trastuzumab perfluorocarbon emulsions and this method has not been extended to other clinically approved antibodies. The methodologies of 19F MRI can improve current limitations of antibody immunotherapy such as quantitative visualization of targeted surface antigens expressed on tumor cells.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 383-389
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contrast-enhanced Magnetic Resonance Imaging of lung cell cultures
    Autorzy:
    Bober, Zuzanna
    Pogoda, Katarzyna
    Aebisher, David
    Tabarkiewcz, Jacek
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/895529.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Lung cancer
    cell cultures
    magnetic resonance imaging
    contrast media
    Gadolinium
    Opis:
    Lung cancer is one of the most common types of cancer diagnosed, and the development of methods to image diseased lung tissue by MRI is of utmost importance. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) was used to noninvasively evaluate spin-spin relaxation time, T1, of lung cell cultures infused with various clinical gadolinium-based contrast media for imaging. In this study we used a clinical 1.5 Tesla scanner and the contrast agents: Omniscan, MultiHance, Gadovist and ProHance. A significant five-fold reduction of T1 relaxation time was obtained.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 251-258
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Trastuzumab Efficacy Quantified by Fluorine-19 Magnetic Resonance Imaging
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Mrs Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895489.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    trastuzumab
    magnetic resonance imaging
    breast cancer cells
    three-dimensional cell culture
    Trastuzumab conjugates
    Opis:
    The purpose of this study was to conjugate Trastuzumab with fluorine-bearing PAMAM dendrimer to compare activities in three-dimensional (3D) cultured breast cancer cells with parent Trastuzumab. An in vitro study was performed to determine cellular responses to fluorinated Trastuzumab conjugates by Magnetic Resonance Imaging (MRI). Breast cancer cells were cultured in 3D geometry. Proton (1H) MRI and Fluorine-19 (19F) MRI were used for visualization of cellular locations within a Hollow Fiber Bioreactor (HFBR) device and to monitor the cellular response to treatment. The results of this study confirm that cell growth is significantly decreased following treatment with Trastuzumab conjugates. The use of fluorinated Trastuzumab conjugates decreases breast cancer cell growth in 3D cultures and allows for tracking of drug delivery to cancer cells via 19F.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 495-503
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of MR relaxation times following trastuzumab treatment of breast cancer cells in a 3D bioreactor
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895234.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    magnetic resonance imaging (MRI)
    breast cancer cell cultures
    hollow-fiber bioreactor (HFBR)
    relaxation time maps
    Opis:
    The three dimensional tumor environment can be mimicked with the use of cells cultured within a hollow-fiber bioreactor (HFBR). In this work, magnetic resonance imaging (MRI) was used to monitor changes in relaxation time in breast cancer cells following treatment with Trastuzumab in a HFBR system. Breast cancer cells were inoculated into the HFBR system and cultured over a period of 4 weeks. Relaxation time maps were generated according to MRI techniques in three dimensional (3D) cultures of MCF7/Her2 breast cancer and MCF7/Neo4 control cells. MRI measurements showed a variation in values of spin-lattice (T1) and spin-spin (T2) relaxation times related to cell density. Differences in both values (T1 and T2) were noted between untreated cells and cells treated with trastuzumab in the HFBR device. Additionally, 1H MRI was able to provide information about drug penetration in breast cancer cell culture organized in 3D. In conclusion, MRI in vitro can provide direct, noninvasive visualization of cell density in 3D geometry and cell viability as a function of drug uptake. Both T1 and T2 values were higher for lower cell density and accordingly both values, T1 and T2, were lower for higher cell density.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 35-41
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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