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    Wyświetlanie 1-7 z 7
    Tytuł:
    CHEMICAL COMPOSITION OF THE ESSENTIAL OIL AND FLAVONOIDS OF THYMUS SERPYLLUM L., GROWING ON TERRITORY OF THE EAST KAZAKHSTAN
    Autorzy:
    Tazabayeva, Kulyash A.
    Sylibaeva, Batiyash
    Powiązania:
    https://bibliotekanauki.pl/articles/895645.pdf
    Data publikacji:
    2018-12-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    essential oils
    flavonoids
    anticancer activity
    Thymus serpyllum
    Opis:
    Thymus serpyllum L. (T.serpyllum) has a great interest as a potential plant component, which is used in the production of fermented milk products with anticancer effect. The plant material was collected at the flowering stage. Chemical composition of essential oil and flavonoids from the aerial parts of the T. serpyllum, grown in the Southern Altai of the East Kazakhstan region, has been investigated for the first time. Output of the essential oil received from the aerial part of the plant in the flowering stage was on average 0,2%. Forty-one compounds were identified in T. serpyllum essential oil, which accounts for 96, 1% of the total oil. The main components of the oil were thymol (41,8%), γ-terpinene (15,3%), o-cymene (10,9%). Apart from the composition of essential oils, there were shown some flavonoids, such asapigenin 7 glucoside (0.24 % of dried plant material), luteolin (0,039 %), quercetin (0,006 %), which demonstrated a cytotoxic effect on cancer cells. In our experiments, luteolin had greater cytotoxic effect on cancer cells HCT-15 than quercetin. IC50 value of quercetin (100 μM) was higher than that of luteolin (50 μM).
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1329-1337
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antimicrobial Activity of the Essential oil of Thymus capitatus against Helicobacter pylori
    Autorzy:
    güvenir, meryem
    Hanoglu, Azmi
    Hanoglu, Duygu
    Suer, Kaya
    Baser, Husnu Can
    Ozkum Yavuz, Dudu
    Sanlıdag, Tamer
    Powiązania:
    https://bibliotekanauki.pl/articles/895252.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    helicobacter pylori
    Thymus capitatus
    in vi
    essential oil
    Opis:
    Helicobacter pylori (H.pylori) is an infective agent and the main resourceful factor of chronic, active ot type B gastritis, peptic and duodenal ulcer, gastric carcinoma and mucosa-associated lymphoid tumors. Nowadays, pharmological treatment of H. pylori infections attract attention beside antibiotic treatment. The aim of this study is to analyse the chemical composition of the essential oils of Thymus capitatus and the antimicrobial activity against H. pylori. Aerial parts of wild growing plant materials were collected during flowering stage from three different locations. Essential oil composition analyses were performed simultaneously by GC-FID and GC-MS systems. The antimicrobial activity of the essential oil were tested by broth dilution method. The thymol percentage was determined as more than half of the essential oil composition of Thymus capitatus-Yedidalga (51.9%) and Thymus capitatus –Yıldırım (57.1%); however, the composition of thymol was 47.2% followed by 15.1% (p-cymene), 10.0% (-terpinene) and 5.7% (carvacrol) for Thymus capitatus-Boğaz/Girne.The essential oil from Thymus capitatus- Boğaz/Girne showed the lowest MIC and MBC values and the strongest bactericidal activity against H. pylori compared to the other tested essential oils. Bactericidal efficacy of essential oil of Thymus capitatus on H. pylori could have been affected due to the varied rates of major compounds. Thymus capitatus essential oil could be an alternative way for the treatment of H. pylori infections.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 155-160
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    DIPSACUS FULLONUM L. LEAVES AND ROOTS - IDENTIFICATION OF THE COMPONENTS OF THE ESSENTIAL OILS AND ALPHA-AMYLASE INHIBITORY ACTIVITIES OF METHANOLIC EXTRACTS
    Autorzy:
    Witkowska-Banaszczak, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/895320.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    essential oil composition
    methanolic extract
    alpha-amylase inhibition
    Opis:
    Abstract: Dipsacus fullonum L. syn. D. sylvestris is a biennial plant from the Dipsacaceae family. It grows in Europe, North Africa and Asia Minor. It has been used in folk medicine mainly to treat Lyme disease. This study was undertaken to identify and compare the components of the essential oils from dried and fresh roots, which are usually applied as medicinal agents, as well as those of the essential oils from dried and fresh leaves, used less frequently. The essential oils from the Dipsacus fullonum leaves and roots were analysed by the GC and GC-MS analysis. 18 components were identified in the essential oil from the fresh leaves, whereas 37 were recognised in the oil from the dried leaves; 10 components were identified in the essential oil from the fresh roots and 40 in that from the dried roots. Phytol was the main component in the essential oil from the leaves, whereas n-hexadecanoic acid was predominant in the roots. The α -amylase inhibition has been proven for methanolic extracts of D. fullonum leaves and roots. The strongest activity was demonstrated by the extract from fresh leaves of D. fullonum and showed an effect about one hundred times weaker than acarbose.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 951-957
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analiza olejku eterycznego z Galium aparine.
    Analysis of essential oil of Galium aparine.
    Autorzy:
    Antoniak, Katarzyna
    Dudek-Makuch, Marlena
    Bylka, Wiesława
    Powiązania:
    https://bibliotekanauki.pl/articles/762669.pdf
    Data publikacji:
    2019-12-11
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    aktywność biologiczna
    olejek eteryczny
    Galium aparine
    essential oils
    biological activities
    Opis:
    Summary Galium aparine L. (clivers, goosegrass) (Rubiaceae) is used in folk medicine as diuretic and medicinal plant alleviating different dermatoses as psoriasis, seborrheic dermatitis, eczema, and improves the immune system. So far, scientific studies have shown as a main constituents: iridoids (mainly asperuloside), flavonoids (luteolin, chrysoeriol, apigenin and quercetin derivatives), numerous of phenolic acids and phytosterols. Previous studies confirmed antimicrobial, antioxidant and cytotoxic activity of clivers. The aim of this work was to investigate the chemical profile of essential oil isolated from G. aparine collected in Poland. The essential oil was extracted from the herb of G. aparine by hydrodistillation in Deryng-type apparatus and the volatile constituents were identified by gas chromatography coupled with mass spectrometry (GC-MS). 0,1 ml of essential oil (3,33 ml/kg) was obtained from the of G. aparine herb, in which 74 volatile ingredients were identified (100%). According to GC/MS analysis 9-diazo-9H-fluorene (31,93%), palmitic acid and dihomo-γ-linolenic acid (8,89%) were as major constituents. 9-diazo-9H-fluorene is very rare in the plant world, previously identified only in Bidens pilosa. Terpene compounds represented 22,31% of essential oil, including 15 sesquiterpenes (18,23%), 6 monoterpenes (2,00%) and 1 diterpene (3,08%). The other active ingredients of the oil include: phytol, β-ionone, anethole, spatulenol, α-cadinol, phenylethyl alcohol, eugenol, methyleugenol, α-carvacrol, α-caryophyllene, α-terpineol, isoaromadendren epoxide, carvone, linalool, santalol, β-farnesene and eucalyptole. The ingredients of the essential oil are multi-directional activity - anti-inflammatory, antimicrobial, anti-cancer, antiproliferative, effect on angiogenesis, and also have occlusive properties. Quantify and a number of ingredients of the essential oil have proven that it may be one of the bioactive important fractions of the clivers herb and partly justify the traditional use of G. aparine.
    Streszczenie Galium aparine L. (przytulia czepna) (Rubiaceae) jest stosowana w medycynie ludowej jako diuretyk i środek łagodzący różne schorzenia skóry. W wyniku dotychczasowych badań stwierdzono, że głównymi związkami ziela są irydoidy, flawonoidy, kwasy fenolowe i fitosterole. Badania naukowe potwierdziły aktywność przeciwdrobnoustrojową, antyoksydacyjną i cytotoksyczną surowca. Celem naszych badań była analiza składników olejku lotnego otrzymanego z rosnącego w Polsce G. aparine. Olejek otrzymano metodą hydrodestylacji w aparacie Derynga, a jego skład analizowano metodą GC-MS. W efekcie otrzymano 0,1 ml olejku (3,33 ml/kg), w którym zidentyfikowano 74 składniki (100%). Dominującymi związkami były: 9-diazo-9H-fluoren (31,93%), który dotąd został wykryty jedynie w Bidens pilosa oraz kwasy palmitynowy i dihomo-γ-linolenowy (8,89%). Związki terpenowe, które stanowiły 22,31% olejku, reprezentowane były przez 15 seskwiterpenów (18,23%), 6 monoterpenów (2,00%) i 1 diterpen (3,08%). Ze względu na wykazaną w licznych pracach aktywność biologiczną, na uwagę zasługują takie składniki olejku, jak: fitol, β-jonon, anetol, spatulenol, α-kadinol, alkohol fenyloetylowy, eugenol, metyloeugenol, α-karwakrol, α-kariofilen, α-terpineol, epitlenek izoaromadendrenu, karwon, linalol, santalol, β-farnezen i eukaliptol. Zawartość oraz skład olejku otrzymanego z analizowanego przez nas surowca wskazuje, że może być jedną z istotnych frakcji czynnych surowca i częściowo uzasadniać tradycyjne zastosowanie G. aparine.
    Źródło:
    Farmacja Polska; 2019, 75, 10; 536-541
    0014-8261
    2544-8552
    Pojawia się w:
    Farmacja Polska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemical composition, antimicrobial and cytotoxic activity of essential oils of Algerian Thymus vulgaris L.
    Autorzy:
    Abdelli, Wafae
    Bahri, Fouad
    Sysak, Angelika
    Szumny, Antoni
    Pawlak, Aleksandra
    Obmińska-Mrukowicz, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/895715.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    essential oil
    GC-MS
    antimicrobial activity
    cytotoxic activity
    GC-FID
    Thymus vulgaris L
    Opis:
    This study analyzed chemical composition of the essential oils (EOs) of Thymus vulgaris L., harvested in two regions of northwest Algeria (Tlemcen and Mostaganem), and evaluated their antimicrobial and cytotoxic activity. Fifty one compounds representing 99.99% and 100% of total thyme oil of Mostaganem (EO.TM) and Tlemcen (EO.TT), respectively were identified by GC-FID and GC-MS. Carvacrol was a dominant compound in both oils (89.15 and 82.42%). The antimicrobial activity, demonstrated by disc diffusion and broth macrodilution methods, showed a strong inhibitory effect of the oils on seven reference strains tested and particularly on Bacillus cereus ATCC 10876 and Candida albicans ATCC 10231. A cytotoxicity assay for two normal and two cancer cell lines indicated the highest sensitivity of canine B-cell lymphoma cell line (CLBL-1) for which IC50 values were 35.39 ± 9.0 (EO.TT) and 84.51± 3.2 (EO.TM). Murine fibroblast cell line (3T3), with IC50 116.97 ± 2.7 for EO.TT and 146.29 ± 0.5 for EO.TM was the most resistant line.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1051-1059
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemical profile and antibacterial activity of essential oils from leaves and fruits of Gaultheria procumbens L. cultivated in Poland
    Autorzy:
    Magiera, Anna
    Sienkiewicz, Monika
    Olszewska, Monika
    Kicel, Agnieszka
    Michel, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/895472.pdf
    Data publikacji:
    2019-02-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    essential oil
    antibacterial activity
    chemical composition
    methyl salicylate
    Gaultheria procumbens L
    GC-FID/MS analysis
    Opis:
    Essential oils (EOs) of Gaultheria procumbens were obtained by hydrodistillation with the yield of 1.30% ± 0.05 (v/dw) for leaves and 2.68% ± 0.08 (v/dw) for fruits. The GC-FID/MS analysis led to the identification of 64 volatile components, among which 27 were found in leaf EO, 49 in fruit EO, and 59 analytes were detected for the first time in G. procumbens. Methyl salicylate, which is known as a potent anti-inflammatory agent, was the dominant component making up to 97.5% and 99.8% of the total fruit and leaf EOs, respectively. The remaining volatiles of the leaves included mainly monoterpenes (α-pinene, β-pinene, limonene), methyl-o-anisate, massoilactone, spiro[4,5]decane-1-one, and aliphatic alcohols (heptan-2-ol, octan-1-ol), while the fruit EO contained apart from the dominant aliphatic and aromatic alcohols (benzyl alcohol, heptan-2-ol, p-cymen-7-ol) also carboxylic acids (3-hydroxyphenylacetic acid, heptanoic acid, octanoic acid) and aldehydes (hexanal, furfural, pent-4-enal). The antibacterial activity of the EOs was evaluated using a microdilution broth method against twelve reference strains, as well as clinical and environmental isolates. Differences between activity parameters of both EOs were not statistically significant (p > 0.05) for most tested bacteria. On the other hand, both EOs were significantly more effective against Gram-negative (MIC, 8.2-10.0 mg/mL) than Gram-positive bacteria (MIC, 13.5-16.7 mg/mL). Leaves and especially fruits of G. procumbens cultivated in Poland were proved valuable sources of methyl salicylate-rich EOs of moderate antibacterial activity, which, therefore, could partly explain the traditional use of the plant materials and the EOs in the treatment of bacterial infections-related inflammatory disorders.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 93-102
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    GC-MS Analysis and Biological activity of Essential Oil of Fruits, Needles and Bark of Pinus pinea grown wildly in Jordan
    Autorzy:
    Halloum, Baha
    Shakya, Ashok K.
    Elagbar, Zaha A.
    Naik, Rajashri R.
    Powiązania:
    https://bibliotekanauki.pl/articles/895316.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    antibacterial activity
    essential oils
    antioxidant activity
    DPPH radical scavenging activity
    β-carotene bleaching assay
    Pinus pinea
    Opis:
    Essential oils from needles, fruits and bark was extracted from Pinus pinea L. (stone pine) grown wildly in Jordan. The chemical composition, antibacterial activity, antioxidant activity of essential oils was evaluated. The chemical compositions were identified using Gas-Chromatography-Mass spectrometry (GC-MS) and retention Indices (Van den Dool & Kratz). The results show that the essential oil obtained from needles composed mainly of Guaiol (12.7%), limonene (11.42%), and β-caryophyllene (7.61%), while fruit contains limonene (32.56%), and α-pinene (6.78%). The essential oils from barks were rich in β-caryophyllene (16.51%), limonene (14.83%), caryophyllene oxide (11.83%), and longifolene (7.51%). In vitro, antibacterial activity of the essential oil samples was evaluated using agar-well diffusion method against three different strains of bacteria (Gram¬-positive bacteria: Staphylococcus aureus and Gram-negative bacteria: Klebsiella pneumoniae and Escherichia coli). The results showed that essential oil showed appreciable antibacterial activity against S. aureus. The essential oil from fruit exhibited weak antibacterial activity against E. coli and K. pneumoniae. Essential oils of P. pinea showed appreciable antioxidant activity in-vitro.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 825-831
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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