Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "Wicha" wg kryterium: Wszystkie pola

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-3 z 3
    Tytuł:
    Profesor Sir Derek Barton : nota w dwudziestą piątą rocznicę śmierci
    Professor Sir Derek barton : a note on the twenty fifth death anniversary
    Autorzy:
    Wicha, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/2200415.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Opis:
    Biographical sketch and the legacy of Professor D. H. R. Barton are shortly presented on the occasion of the twenty fifth anniversary of his death.
    Źródło:
    Wiadomości Chemiczne; 2023, 77, 3-4; 145--151
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Droga pod słońce. Wczesna historia witaminy D
    The route against the sun. Early history of vitamin D
    Autorzy:
    Wicha, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172567.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    witamina D
    biosynteza i żywienie
    sterole
    badanie struktury
    światło ultrafioletowe
    dieta przeciwkrzywicza
    historia witaminy D
    vitamin D
    biosynthesis
    nutrition
    sterols
    structural investigations
    ultraviolet light
    antirachitic diet
    Opis:
    Two natural products are called „vitamin D”: (1) vitamin D3 which is biosynthesized in humans and animals and (2) vitamin D2 which is generated in photochemical rearrangement of a sterol of fungy – ergosterol (Fig. 1 and 2). The vitamins D are further metabolized (Scheme 1) first into 25-hydroxy- and then into 1.,25-dihydroxy derivatives in various tissues. The compounds control the calcium transport and act as a cell growth regulator important for tumor prevention. The early history of vitamin D stems from outburst of rickets at the beginning of the industrialization era. Rickets was a child bond disease that often led to a permanent disability. A comprehensive description of the rickets was presented by D. Whistler ( 1619–1684) and then F. Glisson (1597–1677) and coauthors. Jędrzej Śniadecki ( 1768–1838) was the first who associated the rickets with the sunlight. In his book “On the Physical Education of Children” Śniadecki stated that exposition of a child’s body to a direct action of sunlight is the most efficient method for the prevention and the cure of rickets (Illustrations 1 and 2). T. A. Palm in 1890 observed that the rickets is rare in countries where sunshine is abundant and prevalent whenever there is a little of sunlight. The first experimental evidence on the sunlight effects in rickets were presented by J. R aczyński in 1912 who postulated that the sunlight affects metabolic processes in blood related to calcium transport (Illustration 3 and 4). E. Mellanby showed (1919) that the disease is connected to the lack of certain dietary factors and he recommended the use of cod liver – oil. K. Huldschinsky experimentally proved that UV irradiation cures the rickets. The Mellanby’s and Huldschinsky’s observations were confirmed by clinical studies in 1922. E.V. McCollum has developed efficient methods for “biological analysis” of food and named anti-rachitic factor as vitamin D.H. Steenbock and A.F. Hess in 1924 found independently that various food products gain anti-rachitic properties after being irradiated with a UV lamp. A.F. Hees and A. Windaus showed that irradiation of ergosterol affords a product with high anti-rachitic activity. In 1919 the first structure for cholesterol has been proposed by A. Windaus (Scheme 2, Fig. 3) and then with contribution of H. Wieland it was modified to the “Wieland-Windaus” structure (1928, Nobel Price lectures, Fig. 4). O. Diels’ investigation on dehydratation of cholesterol (Fig. 5) and J.D. Bernal’s crystallographic measurements of ergosterol challenged the Wieland-Windaus structure. Finally, the correct structure for cholic acid and sterols was deduced by O. Rosenheim and H. King (Fig. 6). In 1932 crystalline vitamin D2 was prepared in the Windaus laboratory (Scheme 3). In 1935 vitamin D3 was isolated from a fish-oil and the same compound was synthesized from cholesterol (Illustration 5). The structure of vitamin D2 was elucidated by Windaus in 1935 (Illustration 6) and confirmed by X-ray studies in 1948. Scientific contributions of Adolf Windaus are associated with his highest ethical standards and non-conformist political position in the national-socialist age.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 7-8; 671-696
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hormony steroidowe, leki przeciwzapalne, pigułki antykoncepcyjne. związki i ludzie : notatki historyczne (część I i II)
    Hormones, antiinflammatory drugs, contraceptive pills. compounds and the people : historic notes (part I and II)
    Autorzy:
    Wicha, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1409983.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    notatki historyczne
    steroidy
    hormony płciowe
    kortykosteroidy
    pigułki antykoncepcyjne
    transformacje steroidowe
    synteza totalna
    historic notes
    steroids
    sex hormones
    corticosteroids
    contraceptive pills
    steroid transformations
    total synthesis
    Opis:
    A short historical outlook of steroid hormones isolation, structure elucidation and hormonal drugs development following by a survey of contraceptive therapeutics syntheses and advancements is given. Structural evolution of the first pills, “the pill”, to the presently used oral contraceptives for women is scrutinized. Comments on activities of selected major researchers in the field: Josef Fried, Russell E. Marker, Arthur J. Birch, Carl Djerassi, Georgy G. Pincus, M. C. Chang, John Rock, Igor V. Torgov, Zoltan G. Hajos and Herchel Smith from the personal prospect are presented. Steroid sex hormones, estrogens (female), androgens (male) and gestagens (progesterone, pregnancy hormone) were isolated and identified as chemical entities in 20-tiest and 30-ties of the 20th century. Development of partial synthesis of basic hormones from cholesterol made possible the initial steroid drugs production: Testosterone propionate and 17a-Methyltestosterone (Ciba) as well as Proviron, Progynon, Proluton (Schering AG). In 1940th and 1950th corticosteroids were isolated and recognized as “magic” anti-inflammatory and antiarthritic drugs. Growing demand for antiarthritic drugs in 1950th stimulated search for new corticosteroid analogues and new steroid row materials. Exploration of Mexican plant Dioscorea “cabeza” by Synthex SA provided economical starting material, diosgenin, and opened the new prospects for hormonal drug research and the production. Subsequently, highly active corticosteroid analogues were developed by several pharmaceutical companies and 19-norprogesterone analogues of high gestagenic activity were synthesized - Norethisterone (Synthex) and Norethyndrel (Searle). Complex studies on the application of Norethyndrel as oral contraceptive for women were carried out in the Worcester Foundation for Experimental Biology. In 1959 the first drug “the pill”, which was developed on the grounds of Searls’ Norethyndrel - Enovid was registered by Food and Drug Administration in the USA. Shortly after that Norlutin, based upon Synthex’s Norethisterone, had also been approved for application. Commercial success of “the pill”, Enovid and Norlutin, triggered a broad research aimed at the partial synthesis and application of related progesterone analogues. In the end of 1950th and the beginning of 1960th the total synthesis of estrogens and 19-norsteroids gained practical importance. On these grounds Norgestrel and its active enancjomer Levonorgestrel were developed and commercialized by Wyeth Laboratories Inc. in the USA as the first contraceptive products by total synthesis. Starting from 1970th medicinal applications of corticosteroids gradually diminished, whereas growing attention was given to the development of hormonal contraceptives suitable for general application. Several synthetic modifications of Norethisterone and Levonorgestrel were developed and produced in a large scale. Another class of oral contraceptives stem from the steroid total synthesis developed in the Russell Uclaf laboratories. Structurally these compounds are characterized by 19-norsteroid core and the presence of bulky substituent at the position 11ß, as 4-(N,N-dimethylamino)phenyl- in Mifepristone (RU 486). The synthesis of 19-norpregnane derivatives bearing at the position 11ß various large aromatic or alphatic groups, which currently is receiving a great deal of attention, is considered.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 5-6; 677-753
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies